The effect of diabetes mellitus on osseous healing

被引：168
作者：
Retzepi, M. [1 ]
Donos, N. [1 ]
机构：
[1] UCL Eastman Dent Inst, Div Clin Res, Periodontol Unit, London WC1X 8LD, England
来源：
CLINICAL ORAL IMPLANTS RESEARCH | 2010年 / 21卷 / 07期
关键词：
bone healing; diabetes mellitus; hyperglycaemia; insulin; ossification; BONE-MINERAL DENSITY; GLYCATION END-PRODUCTS; ALKALINE-PHOSPHATASE ACTIVITY; METABOLIC-CONTROL; GROWTH-FACTOR; GLUCOSE-TRANSPORT; INSULIN INCREASES; TYPE-1; RAT; EXPRESSION;
D O I：
10.1111/j.1600-0501.2010.01923.x
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Diabetes mellitus and, in particular, type 1 diabetes has been associated with impaired osseous wound healing properties. The scope of the present review is to discuss the clinical evidence supporting a higher rate of complications during fracture healing in diabetic patients and the histological evidence indicating impaired potential for intramembranous and endochondral ossification in the presence of uncontrolled experimental diabetes. The article further provides a synthesis of our current understanding of the plausible molecular mechanisms underlying the diabetic bone healing pathophysiology and of the role of insulin treatment in promoting osseous healing in the diabetic status. To cite this article:Retzepi M, Donos N. The effect of diabetes mellitus on osseous healing.Clin. Oral Impl. Res. 21, 2010; 673-681.doi: 10.1111/j.1600-0501.2010.01923.x.
引用
收藏
页码：673 / 681
页数：9
相关论文
共 109 条
[51]   Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture [J].
Janghorbani, Mohsen ;
Van Dam, Rob M. ;
Willett, Walter C. ;
Hu, Frank B. .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2007, 166 (05) :495-505
[52]   STIMULATION OF FRACTURE REPAIR BY RECOMBINANT HUMAN BASIC FIBROBLAST GROWTH-FACTOR IN NORMAL AND STREPTOZOTOCIN-DIABETIC RATS [J].
KAWAGUCHI, H ;
KUROKAWA, T ;
HANADA, K ;
HIYAMA, Y ;
TAMURA, M ;
OGATA, E ;
MATSUMOTO, T .
ENDOCRINOLOGY, 1994, 135 (02) :774-781
[53]   Osteopenia in insulin-dependent diabetes mellitus; prevalence and aspects of pathophysiology [J].
Kemink, SAG ;
Hermus, ARMM ;
Swinkels, LMJW ;
Lutterman, JA ;
Smals, AGH .
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2000, 23 (05) :295-303
[54]   Nε-(carboxymethyl)lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression [J].
Kislinger, T ;
Fu, CF ;
Huber, B ;
Qu, W ;
Taguchi, A ;
Yan, SD ;
Hofmann, M ;
Yan, SF ;
Pischetsrieder, M ;
Stern, D ;
Schmidt, AM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (44) :31740-31749
[55]   BONE LOSS AND BONE TURNOVER IN DIABETES [J].
KRAKAUER, JC ;
MCKENNA, MJ ;
BUDERER, NF ;
RAO, DS ;
WHITEHOUSE, FW ;
PARFITT, AM .
DIABETES, 1995, 44 (07) :775-782
[56]   Advanced glycation end-products attenuate human mesenchymal stem cells and prevent cognate differentiation into adipose tissue, cartilage, and bone [J].
Kume, S ;
Kato, S ;
Yamagishi, SI ;
Inagaki, Y ;
Ueda, S ;
Arima, N ;
Okawa, T ;
Kojiro, M ;
Nagata, K .
JOURNAL OF BONE AND MINERAL RESEARCH, 2005, 20 (09) :1647-1658
[57]  
Lalla E, 1998, Ann Periodontol, V3, P13, DOI 10.1902/annals.1998.3.1.13
[58]   Intraosseous circulation from physiology to disease [J].
Laroche, M .
JOINT BONE SPINE, 2002, 69 (03) :262-269
[59]  
Lerner U. H., 2002, Journal of Musculoskeletal & Neuronal Interactions, V2, P440
[60]   BONE-MINERAL DENSITY IN CHILDREN AND ADOLESCENTS WITH JUVENILE DIABETES - SELECTIVE MEASUREMENT OF BONE-MINERAL DENSITY OF TRABECULAR AND CORTICAL BONE USING PERIPHERAL QUANTITATIVE COMPUTED-TOMOGRAPHY [J].
LETTGEN, B ;
HAUFFA, B ;
MOHLMANN, C ;
JEKEN, C ;
REINERS, C .
HORMONE RESEARCH, 1995, 43 (05) :173-175
12345678910