More than just acral melanoma: the controversies of defining the disease

被引：20

作者：

Bernardes, Sara S. ^{[1
,2
]}

Ferreira, Ingrid ^{[1
,3
,4
]}

Elder, David E. ^{[5
]}

Nobre, Aretha B. ^{[6
,7
]}

Martinez-Said, Hector ^{[8
]}

Adams, David J. ^{[3
]}

Robles-Espinoza, Carla Daniela ^{[3
,9
]}

Possik, Patricia A. ^{[1
]}

机构：

[1] Brazilian Natl Canc Inst, Program Immunol & Tumour Biol, Rio De Janeiro, Brazil

[2] Univ Fed Minas Gerais, Dept Gen Pathol, Tissue Microenvironm Lab, Belo Horizonte, MG, Brazil

[3] Wellcome Sanger Inst, Expt Canc Genet, Hinxton, England

[4] Univ Libre Bruxelles, Brussels, Belgium

[5] Hosp Univ Penn, Div Anat Pathol, 3400 Spruce St, Philadelphia, PA 19104 USA

[6] Brazilian Natl Canc Inst, Div Pathol, Rio De Janeiro, Brazil

[7] Univ Fed Rio de Janeiro, Maternidade Escola, Serv Patol, Rio De Janeiro, Brazil

[8] Inst Nacl Cancerol, Serv Piel & Partes Blandas, Mexico City, DF, Mexico

[9] Univ Nacl Autonoma Mexico, Lab Int Invest Genoma Humano, Santiago De Queretaro, Mexico

来源：

JOURNAL OF PATHOLOGY CLINICAL RESEARCH | 2021年 / 7卷 / 06期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

acral melanoma; epidemiology; histopathology; prognosis; genetics; HIGH-DOSE INTERFERON-ALPHA-2B; NAIL APPARATUS MELANOMA; MALIGNANT-MELANOMA; PATHOLOGICAL FEATURES; GENETIC ALTERATIONS; CUTANEOUS MELANOMA; POOR-PROGNOSIS; KIT EXPRESSION; MUTATIONS; DISTINCT;

D O I：

10.1002/cjp2.233

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Acral melanoma (AM) is a malignant cutaneous melanocytic tumour specifically located on the palms, soles, and nail apparatus, which are areas of glabrous (hairless) skin. Acral lentiginous melanoma, a subtype of AM, represents a histopathological subtype diagnosis of cutaneous melanoma with unique morphological and structural features. Despite clear definitions, the misuse of these terms and the inconsistency in reporting the histopathological features of AM cases have become a major obstacle to the study of the disease. In this review, we discuss the epidemiology, histopathological features, prognosis, and genetic profile of AM, highlighting the differences observed when histopathological subtypes are considered. The increasing global effort to characterise AM cases from ethnically diverse populations would benefit greatly from a more consistent classification of the disease.

引用

页码：531 / 541

页数：11

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