The Application of Mesenchymal Stem Cells in the Treatment of Liver Diseases: Mechanism, Efficacy, and Safety Issues

被引：29
作者：
Yang, Ya [1 ]
Zhao, Yalei [1 ]
Zhang, Lingjian [1 ]
Zhang, Fen [1 ]
Li, Lanjuan [1 ]
机构：
[1] Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Affiliated Hosp 1,Natl Clin Res Ctr Infect Dis, Coll Med,State Key Lab Diag & Treatment Infect Di, Hangzhou, Peoples R China
来源：
FRONTIERS IN MEDICINE | 2021年 / 8卷
关键词：
mesenchymal stem cells; liver diseases; mechanism; efficacy; safety; VERSUS-HOST-DISEASE; HEPATIC STELLATE CELLS; BONE-MARROW; STROMAL CELLS; GROWTH-FACTOR; IMMUNOMODULATORY PROPERTIES; EXTRACELLULAR VESICLES; MYELOMONOCYTIC CELLS; ALCOHOLIC CIRRHOSIS; CURRENT SITUATION;
D O I：
10.3389/fmed.2021.655268
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Mesenchymal stem cell (MSC) transplantation is a novel treatment for liver diseases due to the roles of MSCs in regeneration, fibrosis inhibition and immune regulation. However, the mechanisms are still not completely understood. Despite the significant efficacy of MSC therapy in animal models and preliminary clinical trials, issues remain. The efficacy and safety of MSC-based therapy in the treatment of liver diseases remains a challenging issue that requires more investigation. This article reviews recent studies on the mechanisms of MSCs in liver diseases and the associated challenges and suggests potential future applications.
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页数：12
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