Clomiphene Citrate versus Recombinant FSH in intrauterine insemination cycles with mono- or bi-follicular development

被引：6
作者：
Tokgoz, Vehbi Yavuz [1 ]
Sukur, Yavuz Emre [2 ]
Ozmen, Batuhan [2 ]
Sonmezer, Murat [2 ]
Berker, Bulent [2 ]
Aytac, Rusen [2 ]
Atabekoglu, Cem Somer [2 ]
机构：
[1] Eskisehir Osmangazi Univ, Dept Obstet & Gynecol, Fac Med, Eskisehir, Turkey
[2] Ankara Univ, Dept Obstet & Gynecol, Fac Med, Ankara, Turkey
来源：
JORNAL BRASILEIRO DE REPRODUCAO ASSISTIDA | 2021年 / 25卷 / 03期
关键词：
intrauterine insemination; follicle stimulating hormone (FSH); ovarian stimulation; clomiphene citrate; mono-follicular; bi-follicular; OVARIAN STIMULATION; PREGNANCY; GONADOTROPIN; HYPERSTIMULATION; FOLLICLES; ESTRADIOL; COUPLES; NUMBER; WOMEN; IUI;
D O I：
10.5935/1518-0557.20200106
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: The present study aims to assess the success of controlled ovarian stimulation in intrauterine insemination cycles stimulated by recombinant-FSH and Clomiphene citrate for either mono- or bi-follicular development. Methods: We assessed 870 infertile patients treated with controlled ovarian stimulation in intrauterine insemination cycles at a university-based infertility clinic between January 2012 and December 2017. We compared the cycles stimulated by clomiphene citrate and recombinant-FSH in two set-ups; mono- and bi-follicular development. The main outcome measure was the clinical pregnancy rate per cycle. Results: The demographic and cycle parameters were similar between the groups, except for endometrial thickness on the day of hCG administration, which was higher in the recombinant-FSH group than the clomiphene citrate group. The overall clinical pregnancy rates in clomiphene citrate and recombinant-FSH groups were 9.8% and 10.3%, respectively (p=0.940). Regarding the entire cohort, clinical pregnancy was significantly higher in cases of bi-follicular development when compared to mono-follicular development (16.8% vs. 10.2%, respectively; p=0.009). Conclusions: Clomiphene citrate and recombinant-FSH have similar success rates in terms of clinical pregnancy, in either mono-follicular development or bi-follicular development. Clomiphene citrate and recombinant-FSH cycles resulted in comparable rates of bifollicular development, which significantly increases clinical pregnancy rate. Clomiphene citrate and recombinant-FSH have similar success rates in terms of clinical pregnancy, in either mono-follicular development or bi-follicular development.
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页码：383 / 389
页数：7
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