Vasoactive intestinal peptide alleviates food allergy via restoring regulatory B cell functions

被引：10
|
作者：
Zeng, Hao-Tao [1 ,2 ,3 ,4 ]
Zhao, Miao [1 ,2 ,3 ,4 ,5 ]
Yang, Shao-Bo [6 ]
Huang, Huang [7 ]
Geng, Xiao-Rui [1 ,2 ,3 ,4 ,5 ]
Liu, Jiang-Qi [1 ,2 ,3 ,4 ,5 ]
Yang, Gui [1 ,2 ,3 ,4 ,5 ]
Li, Dong-Cai [1 ,2 ,3 ,4 ]
Yang, Li -Tao [1 ,2 ,3 ,4 ,5 ]
Zheng, Peng-Yuan [7 ]
Yang, Ping-Chang [4 ]
机构：
[1] Shenzhen Univ, Affiliated ENT Hosp, Sch Med, Shenzhen, Guangdong, Peoples R China
[2] Longgang ENT Hosp, Shenzhen, Guangdong, Peoples R China
[3] Shenzhen ENT Inst, Shenzhen, Guangdong, Peoples R China
[4] Shenzhen Univ, Sch Med, Res Ctr Allergy & Immunol, Shenzhen, Guangdong, Peoples R China
[5] McMaster Univ, Brain Body Inst, Hamilton, ON, Canada
[6] Chinese Peoples Liberat Army Gen Hosp, Dept Cadre Clin, Beijing, Peoples R China
[7] Zhengzhou Univ, Affiliated Hosp 5, Dept Gastroenterol, Zhengzhou, Henan, Peoples R China
来源：
IMMUNOBIOLOGY | 2019年 / 224卷 / 06期
关键词：
Food allergy; Intestine; Regulatory B cell; Immune regulation; TSP1; T-CELLS; IL-10; MECHANISMS; EXPRESSION; RESPONSES; CHILDREN; RNA; VIP;
D O I：
10.1016/j.imbio.2019.08.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The immune regulatory cell dysfunction is associated with many immune diseases including food allergy (FA). This study aims to investigate the role of vasoactive intestinal peptide (VIP) in the maintenance of regulatory B cell (Br cell)'s immune suppressive functions by stabilizing thrombospondin (TSP1) expression. In this study, blood samples were collected from patients with food allergy (FA) and healthy control (HC) subjects. Br cells were isolated from the samples through flow cytometry cell sorting and analyzed by immunological approaches to determine the immune regulatory capacity. We found that the immune suppressive functions of Br cells were impaired in FA patients. The serum VIP levels were associated with the production of immune suppressive function-related mediators (interleukin-10, IL-10) of Br cells in FA patients. VIP counteracted IL-10 mRNA decay in Br cells by up regulating the TSP1 expression. TSP1 inhibited tristetraprolin (TTP) to prevent IL-10 mRNA decay in Br cells. Administration of VIP inhibited FA response through restoration of immune suppressive functions in Br cells. In conclusion, administration of VIP can alleviate FA response through up regulating expression of TSP1 to stabilize IL-10 expression in FA Br cells and recover the immune regulatory functions. The results have translational potential for the treatment of FA and other disorders associated with immune regulatory dysfunction of Br cells.
引用
收藏
页码：804 / 810
页数：7
相关论文
共 50 条
  • [41] Ovalbumin-induced food allergy suppression via regulatory T cell expansion mediated by a TNFR2 agonist in mice
    Inoue, Masaki
    Tsuji, Yuta
    Shibata, Saya
    Okuda, Mei
    Najima, Chihiro
    Yamasaki, Honoka
    Tsunoda, Shin-ichi
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2024, 737
  • [42] Vasoactive intestinal peptide/vasoactive intestinal peptide receptor relative expression in salivary glands as one endogenous modulator of acinar cell apoptosis in a murine model of Sjogren's syndrome
    Hauk, V.
    Calafat, M.
    Larocca, L.
    Fraccaroli, L.
    Grasso, E.
    Ramhorst, R.
    Perez Leiros, C.
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2011, 166 (03) : 309 - 316
  • [43] Tolerogenic CX3CR1+ B cells suppress food allergy-induced intestinal inflammation in mice
    Liu, Z. -Q.
    Wu, Y.
    Song, J. -P.
    Liu, X.
    Liu, Z.
    Zheng, P. -Y.
    Yang, P. -C.
    ALLERGY, 2013, 68 (10) : 1241 - 1248
  • [44] Vasoactive intestinal peptide induces vascular endothelial growth factor production in human HaCaT keratinocytes via MAPK pathway
    Yu, Xiao-Jing
    Ren, Xiao-Hong
    Xu, Yong-Hao
    Chen, La-Mei
    Zhou, Chun-Lei
    Li, Chun-Yang
    NEUROPEPTIDES, 2010, 44 (05) : 407 - 411
  • [45] Establishment of a 3-Dimensional Intestinal Cell Model to Simulate the Intestinal Mucosal Immune System for Food Allergy Investigations
    Fu, Linglin
    Lin, Wanglei
    Wang, Chong
    Wang, Yanbo
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [46] Galectin-9 in synergy with NF-κB inhibition restores immune regulatory capability in dendritic cells of subjects with food allergy
    Li, Linjing
    Xu, Xuejie
    Wang, Xinxin
    Zhang, Shuang
    Yao, Wenkai
    Liu, Jiangqi
    Liu, Zhiqiang
    Yang, Pingchang
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2023, 213 (02) : 155 - 163
  • [47] Timed hypocaloric food restriction alters the synthesis and expression of vasopressin and vasoactive intestinal peptide in the suprachiasmatic nucleus
    Andrade, JP
    Pereira, PA
    Silva, SM
    Sá, SI
    Lukoyanov, NV
    BRAIN RESEARCH, 2004, 1022 (1-2) : 226 - 233
  • [48] A Synthetic Agonist to Vasoactive Intestinal Peptide Receptor-2 Induces Regulatory T Cell Neuroprotective Activities in Models of Parkinson's Disease
    Mosley, R. Lee
    Lu, Yaman
    Olson, Katherine E.
    Machhi, Jatin
    Yan, Wenhui
    Namminga, Krista L.
    Smith, Jenell R.
    Shandler, Scott J.
    Gendelman, Howard E.
    FRONTIERS IN CELLULAR NEUROSCIENCE, 2019, 13
  • [49] Regulatory effect of vasoactive intestinal peptide on the balance of Treg and Th17 in collagen-induced arthritis
    Deng, Shaohua
    Xi, Yebin
    Wang, Hong
    Hao, Jing
    Niu, Xiaoyin
    Li, Weiyi
    Tao, Yue
    Chen, Guangjie
    CELLULAR IMMUNOLOGY, 2010, 265 (02) : 105 - 110
  • [50] Vasoactive intestinal peptide (VIP)-mediated expression and function of steroidogenic acute regulatory protein (StAR) in granulosa cells
    Kowalewski, Mariusz P.
    Dyson, Matthew T.
    Boos, Alois
    Stocco, Douglas M.
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2010, 328 (1-2) : 93 - 103
12345