Subcutaneous injection of water-soluble multi-walled carbon nanotubes in tumor-bearing mice boosts the host immune activity

被引：38
作者：
Meng, Jie [1 ,2 ,3 ]
Yang, Man [1 ,2 ,3 ]
Jia, Fumin [1 ,2 ,3 ]
Kong, Hua [1 ,2 ,3 ]
Zhang, Weiqi [1 ,2 ,3 ]
Wang, Chaoying [4 ]
Xing, Jianmin [5 ]
Xie, Sishen [4 ]
Xu, Haiyan [1 ,2 ,3 ]
机构：
[1] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Biomed Engn, Beijing 100005, Peoples R China
[2] Chinese Acad Med Sci, Sch Basic Med, Beijing 100005, Peoples R China
[3] Peking Union Med Coll, Beijing 100005, Peoples R China
[4] Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Beijing 100080, Peoples R China
[5] Beijing Univ Chinese Med, Ctr Evidence Based Chinese Med, Beijing 100029, Peoples R China
来源：
NANOTECHNOLOGY | 2010年 / 21卷 / 14期
关键词：
COMPLEMENT ACTIVATION; IMMUNOLOGICAL-PROPERTIES; PLASMID DNA; DELIVERY; SIRNA; TOXICITY; SYSTEM;
D O I：
10.1088/0957-4484/21/14/145104
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
The immunological responses induced by oxidized water-soluble multi-walled carbon nanotubes on a hepatocarcinoma tumor-bearing mice model via a local administration of subcutaneous injection were investigated. Experimental results show that the subcutaneously injected carbon nanotubes induced significant activation of the complement system, promoted inflammatory cytokines' production and stimulated macrophages' phagocytosis and activation. All of these responses increased the general activity of the host immune system and inhibited the progression of tumor growth.
引用
收藏
页数：9
相关论文
共 40 条
[21]   Carbon nanotubes conjugated to tumor lysate protein enhance the efficacy of an antitumor immunotherapy [J].
Meng, Jie ;
Duan, Jinhong ;
Kong, Hua ;
Li, Li ;
Wang, Chen ;
Xie, Sishen ;
Chen, Shuchang ;
Gu, Ning ;
Xu, Haiyan ;
Yang, Xian-Da .
SMALL, 2008, 4 (09) :1364-1370
[22]   Nonviral Vectors for Gene Delivery [J].
Mintzer, Meredith A. ;
Simanek, Eric E. .
CHEMICAL REVIEWS, 2009, 109 (02) :259-302
[23]   Water-dispersed single-wall carbon nanohorns as drug carriers for local cancer chemotherapy [J].
Murakami, Tarsuya ;
Sawada, Hirohide ;
Tamura, Goshu ;
Yudasaka, Masako ;
Iijima, Sumio ;
Tsucbida, Kunihiro .
NANOMEDICINE, 2008, 3 (04) :453-463
[24]   Single-Walled and Multi-Walled Carbon Nanotubes Promote Allergic Immune Responses in Mice [J].
Nygaard, Unni C. ;
Hansen, Jitka S. ;
Samuelsen, Mari ;
Alberg, Torunn ;
Marioara, Calin D. ;
Lovik, Martinus .
TOXICOLOGICAL SCIENCES, 2009, 109 (01) :113-123
[25]   Immunization with peptide-functionalized carbon nanotubes enhances virus-specific neutralizing antibody responses [J].
Pantarotto, D ;
Partidos, CD ;
Hoebeke, J ;
Brown, F ;
Kramer, E ;
Briand, JP ;
Muller, S ;
Prato, M ;
Bianco, A .
CHEMISTRY & BIOLOGY, 2003, 10 (10) :961-966
[26]   Functionalized carbon nanotubes for plasmid DNA gene delivery [J].
Pantarotto, D ;
Singh, R ;
McCarthy, D ;
Erhardt, M ;
Briand, JP ;
Prato, M ;
Kostarelos, K ;
Bianco, A .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (39) :5242-5246
[27]   Translocation of bioactive peptides across cell membranes by carbon nanotubes [J].
Pantarotto, D ;
Briand, JP ;
Prato, M ;
Bianco, A .
CHEMICAL COMMUNICATIONS, 2004, (01) :16-17
[28]   Synthesis, structural characterization, and immunological properties of carbon nanotubes functionalized with peptides [J].
Pantarotto, D ;
Partidos, CD ;
Graff, R ;
Hoebeke, J ;
Briand, JP ;
Prato, M ;
Bianco, A .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (20) :6160-6164
[29]   Antitumor Activity and Prolonged Survival by Carbon-Nanotube-Mediated Therapeutic siRNA Silencing in a Human Lung Xenograft Model [J].
Podesta, Jennifer E. ;
Al-Jamal, Khuloud T. ;
Herrero, Maria A. ;
Tian, Bowen ;
Ali-Boucetta, Hanene ;
Hegde, Vikas ;
Bianco, Alberto ;
Prato, Mourizio ;
Kostarelos, Kostas .
SMALL, 2009, 5 (10) :1176-1185
[30]   Complement activation and protein adsorption by carbon nanotubes [J].
Salvador-Morales, C ;
Flahaut, E ;
Sim, E ;
Sloan, J ;
Green, MLH ;
Sim, RB .
MOLECULAR IMMUNOLOGY, 2006, 43 (03) :193-201
1234