Preliminary Results of Betulinic Acid-Loaded Magnetoliposomes - a Potential Approach to Increase Therapeutic Efficacy in Melanoma

被引：0

作者：

Farcas, Claudia Geanina ^{[1
,2
]}

Moaca, Elena Alina ^{[1
]}

Dragoi, Razvan ^{[3
]}

Vaduva, Delia Berceanu ^{[3
]}

Marcovici, Iasmina ^{[1
]}

Mihali, Ciprian Valentin ^{[4
]}

Loghin, Felicia ^{[2
]}

机构：

[1] Victor Babes Univ Med & Pharm Timisoara, Fac Pharm, 2 Eftimie Murgu Sq, Timisoara 300041, Romania

[2] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Fac Pharm, Dept Toxicol, 8 Victor Babes Str, Cluj Napoca 400012, Romania

[3] Victor Babes Univ Med & Pharm Timisoara, Fac Med, 2 Eftimie Murgu Sq, Timisoara 300041, Romania

[4] Vasile Goldis Western Univ Arad, George Emil Palade Electron Microscopy Ctr, Inst Life Sci, 86 Liviu Rebreanu Str, Arad 310414, Romania

来源：

REVISTA DE CHIMIE | 2019年 / 70卷 / 09期

关键词：

betulinic acid; thermosensitive magnetoliposomes; cytotoxicity; melanoma cells; IRON-OXIDE NANOPARTICLES; CHEMOTHERAPY; CYTOTOXICITY; TRANSITION;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Magnetoliposomes were placed into the biomedical spotlight due to their unique structure, preserving also magnetic features valuable for biomedical applications. The present study provides a preliminary evidence of the cytotoxicity induced by betulinic acid-loaded magnetoliposomes (BA-Fe3O4@Lip) on two melanoma cell lines - A375 and B164A5 cells and one healthy cell line - mice epidermis JB6 Cl 41-5a cells, augmented by references to potential biomedical applications. BA-Fe3O4@Lip showed significant cytotoxicity on the melanoma cell lines, compared with the blank liposomal structures. In addition, the healthy cell line displayed good viability rate after exposure to BA-Fe3O4@Lip.

引用

页码：3372 / 3377

页数：6

共 30 条

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