NK cells and trophoblasts: Partners in pregnancy

被引：149
作者：
Parham, P
机构：
[1] Stanford Univ, Sch Med, Dept Struct Biol, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA
来源：
JOURNAL OF EXPERIMENTAL MEDICINE | 2004年 / 200卷 / 08期
关键词：
D O I：
10.1084/jem.20041783
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In placental mammals, viviparity-the production of living young within the mother's body-evolved under the auspices of the immune system. Elements of immunity were incorporated, giving pregnancy a mildly inflammatory character. Formation of the placenta, the organ that feeds the fetus, involves a cooperation between maternal natural killer (NK) cells and fetal trophoblast cells that remodels the blood supply. Recent research reveals that this process and human reproductive success are influenced by polymorphic HLA-C ligands and their killer cell immunoglobulin-like receptors (KIR).
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收藏
页码：951 / 955
页数：5
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