Dissection of prodromal Alzheimer's disease

被引：5

作者：

Sheng, Can ^{[1
,2
]}

Huang, Yue ^{[3
]}

Han, Ying ^{[1
,4
,5
,6
,7
]}

机构：

[1] Capital Med Univ, XuanWu Hosp, Dept Neurol, Beijing 100053, Peoples R China

[2] Tsinghua Univ, Hosp 1, Dept Neurol, Beijing, Peoples R China

[3] UNSW Australia, Sch Med Sci, Fac Med, Sydney, NSW, Australia

[4] Beijing Inst Brain Disorders, Ctr Alzheimers Dis, Beijing, Peoples R China

[5] Natl Clin Res Ctr Geriatr Disorders, Beijing, Peoples R China

[6] Beijing Inst Geriatr, Beijing, Peoples R China

[7] PKU Care Rehabil Hosp, Beijing, Peoples R China

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2018年 / 23卷

基金：

中国国家自然科学基金;

关键词：

Alzheimer's disease; Prodromal; Biomarkers; Neuroimaging; Cerebrospinal Fluid; Support Vector Machine; Clinical Management; Review; MILD COGNITIVE IMPAIRMENT; CEREBROSPINAL-FLUID BIOMARKERS; NEURONAL THREAD PROTEIN; SUPPORT VECTOR MACHINE; AMYLOID-BETA DEPOSITION; FUNCTIONAL CONNECTIVITY; DOUBLE-BLIND; TOPOLOGICAL ORGANIZATION; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES;

D O I：

10.2741/4643

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pathophysiological changes of Alzheimer's Disease (AD) begin decades before clinical symptoms become apparent, providing an important window for early diagnosis and intervention Prodromal stage of AD, a great opportunity for effective treatment and postponing the disease onset, has drawn extensive attention. The application of different biomarkers including neuroimaging, biochemical substances and genes makes AD-related pathology detectable in vivo and exploring novel biomarkers with relatively non-invasive and low cost has intrigued a wide range of interests. To identify individuals with high risk of conversion to AD and apply the research concept of prodromal AD into clinical practice, the utility of various biomarkers for distinguishing prodromal AD is evaluated in this review. Additionally, clinical management focusing on the stage of prodromal AD is summarized in this review for dementia prevention.

引用

页码：1272 / 1291

页数：20

共 121 条

[1] Amyloid and its association with default network integrity in Alzheimer's disease [J].

Adriaanse, Sofie M. ;

Sanz-Arigita, Ernesto J. ;

Binnewijzend, Maja A. A. ;

Ossenkoppele, Rik ;

Tolboom, Nelleke ;

van Assema, Danielle M. E. ;

Wink, Alle Meije ;

Boellaard, Ronald ;

Yaqub, Maqsood ;

Windhorst, Albert D. ;

van der Flier, Wiesje M. ;

Scheltens, Philip ;

Lammertsma, Adriaan A. ;

Rombouts, Serge A. R. B. ;

Barkhof, Frederik ;

van Berckel, Bart N. M. .

HUMAN BRAIN MAPPING, 2014, 35 (03) :779-791

[2] The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease [J].

Albert, Marilyn S. ;

DeKosky, Steven T. ;

Dickson, Dennis ;

Dubois, Bruno ;

Feldman, Howard H. ;

Fox, Nick C. ;

Gamst, Anthony ;

Holtzman, David M. ;

Jagust, William J. ;

Petersen, Ronald C. ;

Snyder, Peter J. ;

Carrillo, Maria C. ;

Thies, Bill ;

Phelps, Creighton H. .

ALZHEIMERS & DEMENTIA, 2011, 7 (03) :270-279

[3] Human gut microbiota: the links with dementia development [J].

Alkasir, Rashad ;

Li, Jing ;

Li, Xudong ;

Jin, Miao ;

Zhu, Baoli .

PROTEIN & CELL, 2017, 8 (02) :90-102

[4] Mild Cognitive Impairment: Cerebrospinal Fluid Tau Biomarker Pathologic Levels and Longitudinal Changes in White Matter Integrity [J].

Amlien, Inge K. ;

Fjell, Anders M. ;

Walhovd, Kristine B. ;

Selnes, Per ;

Stenset, Vidar ;

Grambaite, Ramune ;

Bjornerud, Atle ;

Due-Tonnessen, Paulina ;

Skinningsrud, Anders ;

Gjerstad, Leif ;

Reinvang, Ivar ;

Fladby, Tormod .

RADIOLOGY, 2013, 266 (01) :295-303

[5] Heterogeneity of brain glucose metabolism in mild cognitive impairment and clinical progression to Alzheimer disease [J].

Anchisi, D ;

Borroni, B ;

Franceschi, M ;

Kerrouche, N ;

Kalbe, E ;

Beuthien-Beumann, B ;

Cappa, S ;

Lenz, O ;

Ludecke, S ;

Marcone, A ;

Mielke, R ;

Ortelli, P ;

Padovani, A ;

Pelati, O ;

Pupi, A ;

Scarpini, E ;

Weisenbach, S ;

Herholz, K ;

Salmon, E ;

Holthoff, V ;

Sorbi, S ;

Fazio, F ;

Perani, D .

ARCHIVES OF NEUROLOGY, 2005, 62 (11) :1728-1733

[6]

Andreadou E., 2017, J ALZHEIMERS DIS

[7]

[Anonymous], 2014, FRONT NEUROL

[8] Topologically Convergent and Divergent Structural Connectivity Patterns between Patients with Remitted Geriatric Depression and Amnestic Mild Cognitive Impairment [J].

Bai, Feng ;

Shu, Ni ;

Yuan, Yonggui ;

Shi, Yongmei ;

Yu, Hui ;

Wu, Di ;

Wang, Jinhui ;

Xia, Mingrui ;

He, Yong ;

Zhang, Zhijun .

JOURNAL OF NEUROSCIENCE, 2012, 32 (12) :4307-4318

[9] Aberrant Hippocampal Subregion Networks Associated with the Classifications of aMCI Subjects: A Longitudinal Resting-State Study [J].

Bai, Feng ;

Xie, Chunming ;

Watson, David R. ;

Shi, Yongmei ;

Yuan, Yonggui ;

Wang, Yi ;

Yue, Chunxian ;

Teng, Yuhuan ;

Wu, Di ;

Zhang, Zhijun .

PLOS ONE, 2011, 6 (12)

[10] Etiology and Pathogenesis of Late-Onset Alzheimer's Disease [J].

Balin, Brian J. ;

Hudson, Alan P. .

CURRENT ALLERGY AND ASTHMA REPORTS, 2014, 14 (03)

← 1 2 3 4 5 6 7 8 9 10 →