Modeling of the permeate flux during microfiltration of BSA-adsorbed microspheres in a stirred cell

被引:29
作者
Choi, SW
Yoon, JY
Haam, S
Jung, JK
Kim, JH
Kim, WS
机构
[1] Yonsei Univ, Dept Chem Engn, Nanosphere Proc & Technol Lab, Sudaemoon Ku, Seoul 120749, South Korea
[2] Univ Calif Los Angeles, IDP, Los Angeles, CA 90095 USA
[3] Korea Res Inst Biosci & Biotechnol, Korea Biopilot Plant Div, Taejon 305333, South Korea
关键词
microspheres; stirred cell; flux modeling; resistance-in-series model;
D O I
10.1006/jcis.2000.6940
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
A study on the variation of the permeate flux was performed in a stirred cell charged with microspheres, to investigate the effects of the stirrer speeds (300, 400, and 600 rpm) and the BSA concentration (0.1, 0.2, 0.4, and 0.8 gn) under constant pressure. The permeate flux increased over time before the saturation point, but it began to decrease after that point. An increase of the BSA concentration and the stirrer speed resulted in the rapid increase of the permeate flux. This is contrary to the observation of the conventional filtration experiments using a stirred cell. A resistance-in-series model was employed for the modeling of the permeate flux. The cake resistance (R-c, induced by the concentration polarization of microspheres) and the fouling resistance (Rr, induced by the adsorption of BSA inside the membrane pore) must be considered simultaneously for the modeling. These modeling results were in good agreement with the experimental data. These can be applied to the special system considering both R-c and R-f as well as the general filtration systems using a stirred cell. (C) 2000 Academic Press.
引用
收藏
页码:270 / 278
页数:9
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