Advances in signalling by extracellular nucleotides: the role and transduction mechanisms of P2Y receptors

被引：139
作者：
Communi, D
Janssens, R
Suarez-Huerta, N
Robaye, B
Boeynaems, JM
机构：
[1] Free Univ Brussels, Hop Erasme, Dept Med Chem, B-1070 Brussels, Belgium
[2] Free Univ Brussels, Sch Med, Inst Interdisciplinary Res, B-1000 Brussels, Belgium
来源：
CELLULAR SIGNALLING | 2000年 / 12卷 / 06期
关键词：
nucleotides; purines; G-protein-coupled receptors; P2;
D O I：
10.1016/S0898-6568(00)00083-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Nucleotides are ubiquitous intercellular messengers whose actions are mediated by specific receptors. Since the first clonings in 1993, it is known that nucleotide receptors belong to two families: the ionotropic P2X receptors and the metabotropic P2Y receptors. Five human P2Y receptor subtypes have been cloned so far and a sixth one must still be isolated. In this review we will show that they differ by their preference for adenine ver-sits uracil nucleotides and triphospho versus diphospho nucleotides, as well as by their transduction mechanisms and cell expression. (C) 2000 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：351 / 360
页数：10
相关论文
共 154 条
[1]   THE MULTIDRUG RESISTANCE (MDR1) GENE-PRODUCT FUNCTIONS AS AN ATP CHANNEL [J].
ABRAHAM, EH ;
PRAT, AG ;
GERWECK, L ;
SENEVERATNE, T ;
ARCECI, RJ ;
KRAMER, R ;
GUIDOTTI, G ;
CANTIELLO, HF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (01) :312-316
[2]   Regulation of brain capillary endothelial cells by P2Y receptors coupled to Ca2+, phospholipase C and mitogen-activated protein kinase [J].
Albert, JL ;
Boyle, JP ;
Roberts, JA ;
Challiss, RAJ ;
Gubby, SE ;
Boarder, MR .
BRITISH JOURNAL OF PHARMACOLOGY, 1997, 122 (05) :935-941
[3]   ATP RECEPTOR REGULATION OF ADENYLATE-CYCLASE AND PROTEIN-KINASE-C ACTIVITY IN CULTURED RENAL LLC-PK1 CELLS [J].
ANDERSON, RJ ;
BRECKON, R ;
DIXON, BS .
JOURNAL OF CLINICAL INVESTIGATION, 1991, 87 (05) :1732-1738
[4]   ANALYSIS OF CD36 BINDING DOMAINS - LIGAND SPECIFICITY CONTROLLED BY DEPHOSPHORYLATION OF AN ECTODOMAIN [J].
ASCH, AS ;
LIU, I ;
BRICCETTI, FM ;
BARNWELL, JW ;
KWAKYEBERKO, F ;
DOKUN, A ;
GOLDBERGER, J ;
PERNAMBUCO, M .
SCIENCE, 1993, 262 (5138) :1436-1440
[5]   Cloning and chromosomal localization of the human P2Y1 purinoceptor [J].
Ayyanathan, K ;
Webbs, TE ;
Sandhu, AK ;
Athwal, RS ;
Barnard, EA ;
Kunapuli, SP .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 218 (03) :783-788
[6]  
Baltensperger H, 1997, J BIOL CHEM, V272, P10151
[7]   Detection of local ATP release from activated platelets using cell surface-attached firefly luciferase [J].
Beigi, R ;
Kobatake, E ;
Aizawa, M ;
Dubyak, GR .
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1999, 276 (01) :C267-C278
[8]   Effect of uridine 5'-triphosphate plus amiloride on mucociliary clearance in adult cystic fibrosis [J].
Bennett, WD ;
Olivier, KN ;
Zeman, KL ;
Hohneker, KW ;
Boucher, RC ;
Knowles, MR .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1996, 153 (06) :1796-1801
[9]   P-2-purinergic receptors regulate phospholipase C and adenylate cyclase activities in immortalized Schwann cells [J].
BertiMattera, LN ;
Wilkins, PL ;
Madhun, Z ;
Suchovsky, D .
BIOCHEMICAL JOURNAL, 1996, 314 :555-561
[10]   Selective inhibition of M-type potassium channels in rat sympathetic neurons by uridine nucleotide preferring receptors [J].
Boehm, S .
BRITISH JOURNAL OF PHARMACOLOGY, 1998, 124 (06) :1261-1269
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