The Application of Chitosan and Its Derivatives as Nanosized Carriers for the Delivery of Chemical Drugs and Genes or Proteins

被引:11
|
作者
Tang, Qilin [1 ]
Huang, Gangliang [1 ]
Ran, Rui [1 ]
Huang, Yanghua [1 ]
Lou, Qiaoping [1 ]
Chen, Yuzhu [1 ]
机构
[1] Chongqing Normal Univ, Coll Chem, Chongqing 401331, Peoples R China
关键词
Polysaccharides; carriers; drug delivery; chemical drugs; genes; proteins; IN-VITRO; NANOPARTICLES; SYSTEM; MICROSPHERES; RELEASE; HYDROGELS; THERAPY; NANOGEL; CELLS;
D O I
10.2174/1389450116666151019100106
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The carrier technology provides an intelligent approach for drug delivery by entrapping the drug into a carrier, such as nanoparticles, microspheres, hydrogels, and so on, which can increase the bioavailability of drug, enhance targeting, reduce toxicity and side effects of drug. The polysaccharides, e.g., chitosan and its derivatives, as carriers for delivery of chemical drugs and genes or proteins were summed up herein.
引用
收藏
页码:811 / 816
页数:6
相关论文
共 50 条
  • [1] Targeted delivery of proteins by nanosized carriers
    Solaro, Roberto
    JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2008, 46 (01) : 1 - 11
  • [2] Chitosan and its Derivatives as Chemical Drug Delivery
    Xing, Lei
    Du, Lina
    Luo, Cheng-Qiong
    Zhou, Tian-Jiao
    Zhu, Yong
    Gong, Jia-Hui
    Jin, Yiguang
    Jiang, Hu-Lin
    CURRENT ORGANIC CHEMISTRY, 2018, 22 (07) : 690 - 707
  • [3] Application of chitosan and its derivatives in drug delivery
    Shruthi, Ponsreeram
    Venkatesan, Kotteeswaran
    RESEARCH JOURNAL OF BIOTECHNOLOGY, 2021, 16 (12): : 161 - 172
  • [4] Folic acid decorated chitosan nanoparticles and its derivatives for the delivery of drugs and genes to cancer cells
    John, Agnes Aruna
    Jaganathan, Saravana Kumar
    Ayyar, Manikandan
    Krishnasamy, Navaneetha Pandiyaraj
    Rajasekar, Rathanasamy
    Supriyanto, Eko
    CURRENT SCIENCE, 2017, 113 (08): : 1530 - 1542
  • [5] Application of Chitosan and Its Derivatives in Transdermal Drug Delivery
    Panonnummal, Rajitha
    Kumar, Vrinda S.
    Jayakumar, R.
    Sabitha, M.
    CHITOSAN FOR BIOMATERIALS IV: BIOMEDICAL APPLICATIONS, 2021, 288 : 411 - 446
  • [6] Targeted delivery of low molecular drugs using chitosan and its derivatives
    Park, Jae Hyung
    Saravanakumar, Gurusamy
    Kim, Kwangmeyung
    Kwon, Ick Chan
    ADVANCED DRUG DELIVERY REVIEWS, 2010, 62 (01) : 28 - 41
  • [7] Chitosan and Its Derivatives for Application in Mucoadhesive Drug Delivery Systems
    Ways, Twana Mohammed M.
    Lau, Wing Man
    Khutoryanskiy, Vitaliy V.
    POLYMERS, 2018, 10 (03):
  • [8] Biocompatibility of Chitosan Carriers with Application in Drug Delivery
    Rodrigues, Susana
    Dionisio, Marita
    Remunan Lopez, Carmen
    Grenha, Ana
    JOURNAL OF FUNCTIONAL BIOMATERIALS, 2012, 3 (03): : 615 - 641
  • [9] Chitosan Derivatives as Carriers for Drug Delivery and Biomedical Applications
    Manna, Sreejan
    Seth, Arnab
    Gupta, Prajna
    Nandi, Gouranga
    Dutta, Ria
    Jana, Subrata
    Jana, Sougata
    ACS BIOMATERIALS SCIENCE & ENGINEERING, 2023, 9 (05) : 2181 - 2202
  • [10] Chitosan and its derivatives for gene delivery
    Lee, Kuen Yong
    MACROMOLECULAR RESEARCH, 2007, 15 (03) : 195 - 201