Antioxidant effect of chamomile tea on the salivary glands of streptozotocin-induced diabetic rats

被引：7

作者：

Perestrelo, Bruna Oliveira ^{[1
]}

de Carvalho, Polliane Morais ^{[1
]}

Souza, Douglas Nesadal ^{[1
]}

Carneiro, Mara Junqueira ^{[3
]}

Goncalves Cirino, Joao Pedro ^{[4
]}

Carvalho, Patricia Oliveira ^{[4
]}

Helena Frankland Sawaya, Alexandra Christine ^{[3
]}

Oyama, Lila Missae ^{[2
]}

Nogueira, Fernando Neves ^{[1
]}

机构：

[1] Univ Sao Paulo, Sch Dent, Dept Biomat & Oral Biol, Sao Paulo, SP, Brazil

[2] Univ Fed Sao Paulo Unifesp, Fac Med Sch, Dept Physiol, Sao Paulo, SP, Brazil

[3] Univ Estadual Campinas Unicamp, Inst Biol, Dept Plant Biol, Campinas, SP, Brazil

[4] Univ Sao Francisco USF, Lab Multidisciplinary Res, Braganca Paulista, SP, Brazil

来源：

BRAZILIAN ORAL RESEARCH | 2022年 / 36卷

关键词：

Antioxidants; Diabetes Mellitus; Salivary Glands; Chamomile; Oxidative Stress; OXIDATIVE STRESS; GLUCOSE; PROFILE;

D O I：

10.1590/1807-3107bor-2022.vol36.0034

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

This study aimed to analyze oxidative stress and the activity of antioxidant enzymes in the salivary glands of streptozotocin (STZ)-induced diabetic rats with ad libitum consumption of chamomile tea in substitution of water for 21 days. Rats were divided in two control groups (untreated control and treated control) and two diabetic groups (untreated diabetic and treated diabetic). Superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) activities, total antioxidant status (TAS), and malondialdehyde (MDA) concentrations were determined. The chemical composition of the chamomile essential oil revealed 39 compounds, accounting for 93.5% of the total oils. The polyphenolic profile of the tea showed the presence of apigenin, luteolin, umbelliferone, and esculetin. SOD, GPx, CAT, and TAS levels were lower in the parotid (PA) diabetic glands, but treatment increased their concentration in both the submandibular (SM) and PA diabetic salivary glands. Increased MDA levels were observed in the PA diabetic glands, which were decreased by the consumption of chamomile tea with a reduction in hyperglycemia compared to that in untreated diabetic rats. However, the SM diabetic glands showed no difference in the MDA content. The consumption of chamomile tea prevented oxidative stress in the PA glands of diabetic rats, exhibiting hypoglycemic and antioxidant effects. Thus, chamomile tea could be a potential candidate for preventing oral complications in diabetes mellitus.

引用

页数：10

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