Nanoemulsion: Concepts, development and applications in drug delivery

被引：863

作者：

Singh, Yuvraj ^{[1
]}

Meher, Jaya Gopal ^{[1
]}

Raval, Kavit ^{[1
]}

Khan, Farooq Ali ^{[1
]}

Chaurasia, Mohini ^{[2
]}

Jain, Nitin K. ^{[3
]}

Chourasia, Manish K. ^{[1
]}

机构：

[1] CSIR, Cent Drug Res Inst, Pharmaceut Div, Lucknow 226031, Uttar Pradesh, India

[2] Amity Univ, Amity Inst Pharm, Lucknow Campus, Lucknow 226028, Uttar Pradesh, India

[3] Dept Biotechnol, CGO Complex,Lodhi Rd, New Delhi 110003, India

来源：

JOURNAL OF CONTROLLED RELEASE | 2017年 / 252卷

关键词：

Nanoemulsion; Clinical trials; In vivo fate; Ostwald ripening; Parenteral; Oral; Drug delivery; LOW-DENSITY-LIPOPROTEIN; IMPROVED ORAL DELIVERY; CHOLESTEROL-RICH MICROEMULSION; OVERCOME MULTIDRUG-RESISTANCE; GLYCOL SURFACE-DENSITY; IN-WATER NANOEMULSIONS; LIPID NANOEMULSION; DROPLET SIZE; ANTIMICROBIAL ACTIVITY; TOPICAL DELIVERY;

D O I：

10.1016/j.jconrel.2017.03.008

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nanoemulsions are biphasic dispersion of two immiscible liquids: eitherwater in oil (W/O) or oil inwater (O/W) droplets stabilized by an amphiphilic surfactant. These come across as ultrafine dispersions whose differential drug loading; viscoelastic as well as visual properties can cater to a wide range of functionalities including drug delivery. However there is still relatively narrow insight regarding development, manufacturing, fabrication and manipulation of nanoemulsions which primarily stems from the fact that conventional aspects of emulsion formation and stabilization only partially apply to nanoemulsions. This general deficiency sets up the premise for current review. Weattempt to explore varying intricacies, excipients, manufacturing techniques and their underlying principles, production conditions, structural dynamics, prevalent destabilization mechanisms, and drug delivery applications of nanoemulsions to spike interest of those contemplating a foray in this field. (C) 2017 Elsevier B. V. All rights reserved.

引用

页码：28 / 49

页数：22

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