KIR-ligand mismatch in allogeneic hematopoietic stem cell transplantation

被引：43
作者：
Malmberg, KJ [1 ]
Schaffer, M
Ringdén, O
Remberger, M
Ljunggren, HG
机构：
[1] Karolinska Univ, Dept Med, Ctr Infect Med, Karolinska Inst,Hosp Huddinge, S-14186 Huddinge, Sweden
[2] Karolinska Univ, Dept Lab Med, Div Clin Immunol, Karolinska Inst,Hosp Huddinge, S-14186 Huddinge, Sweden
[3] Karolinska Univ, Huddinge Hosp, Karolinska Inst, Dept Lab Med,Ctr Allogene Stem Cell Transplantat, S-14186 Huddinge, Sweden
来源：
MOLECULAR IMMUNOLOGY | 2005年 / 42卷 / 04期
关键词：
KIR; stem cell transplantation; natural killer cell; transplantation related mortality; opportunistic infections;
D O I：
10.1016/j.molimm.2004.07.037
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
KIR-ligand mismatch in the graft-versus-host (GVH) direction between donor and recipient in allogeneic stem cell transplantation (ASCT) may trigger NK cell alloreactivity. Such KIR-ligand mismatch has been associated with improved survival after haploidentical ASCT for acute myeloid leukemia (AML). Its role in unrelated ASCT has been more controversial. In an analysis of 190 unrelated ASCTs for hernatological malignancies, we observed that KIR-ligand mismatch was associated with increased transplantation related mortality (TRM) and decreased overall survival. The increased TRM was a consequence of a higher rate of infections. Thus, the presence of alloreactive NK cells can potentially interfere with effective immunity to infections in the early post-transplantation period. Here, we review the discrepancies in published reports on KIR-ligand mismatch in unrelated ASCT. (C) 2004 Elsevier Ltd. All rights reserved.
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收藏
页码：531 / 534
页数：4
相关论文
共 18 条
[1]   Role of KIR ligand incompatibility in hematopoietic stem cell transplantation using unrelated donors [J].
Bornhäuser, M ;
Schwerdtfeger, R ;
Martin, H ;
Frank, KH ;
Theuser, C ;
Ehninger, G .
BLOOD, 2004, 103 (07) :2860-2861
[2]   The impact of donor KIR and patient HLA-C genotypes on outcome following HLA-identical sibling hematopoietic stem cell transplantation for myeloid leukemia [J].
Cook, MA ;
Milligan, DW ;
Fegan, CD ;
Darbyshire, PJ ;
Mahendra, P ;
Craddock, CF ;
Moss, PAH ;
Briggs, DC .
BLOOD, 2004, 103 (04) :1521-1526
[3]   NK cell and DC interactions [J].
Cooper, MA ;
Fehniger, TA ;
Fuchs, A ;
Colonna, M ;
Caligiuri, MA .
TRENDS IN IMMUNOLOGY, 2004, 25 (01) :47-52
[4]   Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants [J].
Davies, SM ;
Ruggieri, L ;
DeFor, T ;
Wagner, JE ;
Weisdorf, DJ ;
Miller, JS ;
Velardi, A ;
Blazar, BR .
BLOOD, 2002, 100 (10) :3825-3827
[5]   Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect [J].
Farag, SS ;
Fehniger, TA ;
Ruggeri, L ;
Velardi, A ;
Caligiuri, MA .
BLOOD, 2002, 100 (06) :1935-1947
[6]   Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors [J].
Giebel, S ;
Locatelli, F ;
Lamparelli, T ;
Velardi, A ;
Davies, S ;
Frumento, G ;
Maccario, R ;
Bonetti, F ;
Wojnar, J ;
Martinetti, M ;
Frassoni, F ;
Giorgiani, G ;
Bacigalupo, A ;
Holowiecki, J .
BLOOD, 2003, 102 (03) :814-819
[7]   NK cell TRAIL eliminates immature dendritic cells in vivo and limits dendritic cell vaccination efficacy [J].
Hayakawa, Y ;
Screpanti, V ;
Yagita, H ;
Grandien, A ;
Ljunggren, HG ;
Smyth, MJ ;
Chambers, BJ .
JOURNAL OF IMMUNOLOGY, 2004, 172 (01) :123-129
[8]  
IGARASHI T, 2004, BLOOD
[9]   SELECTIVE REJECTION OF H-2-DEFICIENT LYMPHOMA VARIANTS SUGGESTS ALTERNATIVE IMMUNE DEFENSE STRATEGY [J].
KARRE, K ;
LJUNGGREN, HG ;
PIONTEK, G ;
KIESSLING, R .
NATURE, 1986, 319 (6055) :675-678
[10]   STIMULATION OF MATURE UNPRIMED CD8+ T-CELLS BY SEMIPROFESSIONAL ANTIGEN-PRESENTING CELLS INVIVO [J].
KOSAKA, H ;
SURH, CD ;
SPRENT, J .
JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (05) :1291-1302
12