Biochemical Evaluation of Copper Compounds Derived from O- and N-/O- Donor Ligands

被引：3

作者：

Akhtar, Muhammad Nadeem ^{[1
]}

Shahid, Muhammad ^{[2
]}

Sadakiyo, Masaaki ^{[3
]}

Ikram, Muhammad ^{[4
]}

Rehman, Sadia ^{[4
]}

Ahmed, Irshad ^{[5
]}

机构：

[1] Univ Agr Faisalabad, Dept Chem, Faisalabad, Pakistan

[2] Univ Agr Faisalabad, Dept Biochem, Faisalabad, Pakistan

[3] Kyushu Univ, Int Inst Carbon Neutral Energy Res I2CNER, Nishi Ku, 744 Moto Oka, Fukuoka 8190395, Japan

[4] Abdul Wali Khan Univ, Dept Chem, Mardan, Pakistan

[5] Islamia Univ Bahawalpur, Dept Pharm, Bahawalpur, Pakistan

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2017年 / 51卷 / 04期

关键词：

copper complexes; benzoate; 3-pyridinepropionic acid; antioxidant activity; alpha-enzyme inhibition; hemolytic activity; STRUCTURAL-CHARACTERIZATION; TRANSITION-METAL; BUTYRYLCHOLINESTERASE; ACETYLCHOLINESTERASE; INHIBITION; COMPLEXES; CHEMISTRY; UREASE;

D O I：

10.1007/s11094-017-1596-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Compounds [Cu-II (2)(benz)(4)(Hbenz)(2)] (1) and [Cu-II(ppa)(2)(H2O)(2)] (n) (2), where benz = benzoate and ppa = 3-pyridinepropionic acid, were synthesized and studied for their 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and the inhibition of enzymes such as acetylcholinesterase (AChE), butyrylcholinesterase (BChE), lipoxygenase (LOX), urease, chymotrypsin and alpha-glucosidase. The synthesized compounds were also studied by hemolytic method for their cytotoxicity and found to be low-toxicity substances. For AChE inhibition, compound 2 showed IC50 = 31.22 +/- 0.45 mu M, as compared to compound 1with IC50 = 36.52 +/- 0.44 mu M. Both compounds showed comparably low activity against BChE and were also active against urease, but compound 1 exhibited selective anti-urease activity. The anti-alpha-glucosidase activity of both compounds was comparable with that of standard drug used.

引用

页码：272 / 276

页数：5

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