The impact of Schiff bases on antibiotic production by Streptomyces hygroscopicus

被引：16
|
作者：
Ilic, Slavica B. [1 ]
Konstantinovic, Sandra S. [1 ]
Savic, Dragisa S. [1 ]
Veljkovic, Vlada B. [1 ]
Gojgic-Cvijovic, G. [2 ]
机构：
[1] Univ Nis, Fac Technol, Leskovac 16000, Serbia
[2] ICTM, Dept Chem, Belgrade 11000, Serbia
来源：
MEDICINAL CHEMISTRY RESEARCH | 2010年 / 19卷 / 07期
关键词：
Streptomyces hygroscopicus; Schiff base; Antibiotic production; Morphology; GROWTH;
D O I：
10.1007/s00044-009-9223-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A media consisting of isatin-Schiff bases (isatin-3-thiosemicarbazone, isatin-3-semicarbazone, and isatin-3-phenylhydrazone) was developed to maximize the production of antibiotics Hexaene H-85 and Azalomycine B by Streptomyces hygroscopicus. The media isatin-3-thiosemicarbazone resulted in the maximum antibiotics concentration of 372 mu g cm(-3) for Hexaene H-85 and 118 mu g cm(-3) for Azalomycine B. The impact of modified media on soil morphology also was investigated.
引用
收藏
页码：690 / 697
页数：8
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