Regulation of Non-Infectious Lung Injury, Inflammation, and Repair by the Extracellular Matrix Glycosaminoglycan Hyaluronan

被引:52
作者
Jiang, Dianhua [1 ]
Mang, Jiurong [1 ]
Noble, Paul W. [1 ]
机构
[1] Duke Univ, Dept Med, Sch Med, Div Pulm Allergy & Crit Care Med, Durham, NC 27710 USA
来源
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY | 2010年 / 293卷 / 06期
关键词
extracellular matrix; glycosaminoglycan; lung injury; IDIOPATHIC PULMONARY-FIBROSIS; TOLL-LIKE RECEPTORS; MURINE MACROPHAGES; TISSUE-INJURY; RECOGNITION; CD44; EXPRESSION; ACTIVATE; TLR4;
D O I
10.1002/ar.21102
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
An important hallmark of tissue remodeling is the dynamic turnover of extracellular matrix (ECM) ECM performs a variety of functions in tissue repair including scaffold formation, modulation of fluid dynamics, and regulating cell behavior During non-infectious tissue injury ECM degradation products are generated that acquire signaling functions not attributable to the native precursor molecules Hyaluronan (HA) is a non-sulfated glycosaminoglycan which is produced in great abundance following tissue injury. It exists both in a soluble form and as side chains on proteoglycans HA has critical roles in development as well as a variety of biological processes including wound healing, tumor growth and metastasis, and inflammation. HA fragments share structural similarities with pathogens and following tissue injury can be recognized by innate immune receptors Elucidating the protean roles of HA in tissue injury, inflammation, and repair will generate new insights into mechanisms of diseases characterized by chronic inflammation and tissue remodeling. Anat Rec. 293:982-985, 2010 (C) 2010 Wiley-Liss, Inc.
引用
收藏
页码:982 / 985
页数:4
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