Synthesis of Novel Derivatives of 1,2,4-Triazoles

被引：9

作者：

Galstyan, Armen S. ^{[1
]}

Ghochikyan, Tariel, V ^{[1
]}

Frangyan, Vardges R. ^{[1
]}

Tamazyan, Rafael A. ^{[2
]}

Ayvazyan, Armen G. ^{[2
]}

机构：

[1] Yerevan State Univ, Fac Chem, 1 A Manoukyan Str, Yerevan 0025, Armenia

[2] NAS RA, Sci & Technol Ctr Organ & Pharmaceut Chem, Mol Struct Res Ctr, 26 Azatutian Ave, Yerevan 0014, Armenia

来源：

CHEMISTRYSELECT | 2018年 / 3卷 / 35期

关键词：

beta-alanine; hydrazinolysis; 1; 3; 4-oxadiazole; oxygen-trapping agent; 2; 4-triazole; CHEMOSELECTIVE REDUCTION; BIOLOGICAL EVALUATION; HYDRAZINE; DESIGN; BONDS; HYDROGENATION; NANOPARTICLES; AGENTS;

D O I：

10.1002/slct.201802243

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A method for the preparation of methyl esters of beta-1,2,4-triazole-substituted alanines by condensation of methyl acrylate with 3,4-disubstituted-5-mercapto-1,2,4-triazoles has been developed. The optimal conditions for the process of hydrazinolysis of N-allyl derivatives of the obtained products were established. It is shown that to prevent the reduction of the allyl group, it is reasonable to carry out the process of hydrazinolysis in the presence of sodium sulfite. Based on hydrazides of beta-1,2,4-triazole-substituted alanines, biheterocyclic compounds of a new structure - 1,2,4-triazole- and 1,3,4-oxadiazole-1,2,4-triazoles were synthesized.

引用

页码：9981 / 9985

页数：5

共 42 条

[1] Preparation and Evaluation of Antibacterial Activity of Some New 1,2,4-Triazole Derivatives [J].

Arafa, W. A. A. .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2010, 47 (05) :1109-1115

[2]

Arakawa Y, 2017, SYNOPEN, V1, P11, DOI 10.1055/s-0036-1588790

[3] The importance of triazole scaffold in the development of anticonvulsant agents [J].

Ayati, Adile ;

Emami, Saeed ;

Foroumadi, Alireza .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 109 :380-392

[4] Synthesis of New Derivatives of 3-Aryl-1,5-dimethyl-1H-[1,2,4]triazolo[4′,3′:1,2]pyrimido[4,5-e][1,3,4]oxadiazines as Potential Antiproliferative Agents [J].

Bakavoli, Mehdi ;

Rahimizadeh, Mohammad ;

Shiri, Ali ;

Akbarzadeh, Marzieh ;

Mousavi, Seyed-Hadi ;

Tayarani-Najaran, Zahra ;

Atapour-Mashhad, Hoda ;

Nikpour, Mohsen .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2011, 48 (01) :183-187

[5] Cyclization of some carbothioamide derivatives containing antipyrine and triazole moieties and investigation of their antimicrobial activities [J].

Bayrak, Hacer ;

Demirbas, Ahmet ;

Demirbas, Neslihan ;

Karaoglu, Sengul Alpay .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (11) :4726-4732

[6] Synthesis and Antifungal Activities of Some New 5,7-Disubstituted[1,2,4]Triazolo[1,5-a]Pyrimidin-6-one Derivatives [J].

Borthakur, Susanta Kumar ;

Borthakur, Sukanya ;

Goswami, Debarshi ;

Boruah, Paran ;

Kalita, Pabitra Kumar .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2016, 53 (06) :2079-2083

[7] Synthesis of β-cydodextrin derivatives functionalized with azobenzene [J].

Casas-Solvas, Juan M. ;

Martos-Maldonado, Manuel C. ;

Vargas-Berenguel, Antonio .

TETRAHEDRON, 2008, 64 (48) :10919-10923

[8] A simple and straightforward approach toward selective C=C bond reduction by hydrazine [J].

Chen, Hao ;

Wang, Jianmin ;

Hong, Xuechuan ;

Zhou, Hai-Bing ;

Dong, Chune .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 2012, 90 (09) :758-761

[9] Metal-Organic Frameworks (MOFs) as Heterogeneous Catalysts for the Chemoselective Reduction of Carbon-Carbon Multiple Bonds with Hydrazine [J].

Dhakshinamoorthy, Amarajothi ;

Alvaro, Mercedes ;

Garcia, Hermenegildo .

ADVANCED SYNTHESIS & CATALYSIS, 2009, 351 (14-15) :2271-2276

[10] Practical synthesis of regioisomeric 5(7)-amino-6,7(4,5)-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazines [J].

Dolzhenko, Anton V. ;

Dolzhenko, Anna V. ;

Chui, Wai-Keung .

TETRAHEDRON, 2007, 63 (52) :12888-12895

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