Charge-monitoring laser-induced acoustic desorption mass spectrometry for cell and microparticle mass distribution measurement

被引：58
作者：
Peng, Wen-Ping
Lin, Huan-Chang
Lin, Hsin-Hung
Chu, Minglee
Yu, Alice L.
Chang, Huan-Cheng
Chen, Chung-Hsuan [1 ]
机构：
[1] Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan
[2] Acad Sinica, Inst Phys, Taipei 115, Taiwan
[3] Acad Sinica, Inst Atom & Mol Sci, Taipei 115, Taiwan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 21期
关键词：
cells; charge detection; ion trap; mass spectrometry; microparticles;
D O I：
10.1002/anie.200700309
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Mass exodus: A mass spectrometer for the rapid measurement of mass distributions of cells and microparticles is described. A discharge process is used to provide cells with thousands of charges so that direct charge measurement can be achieved. This device was used to measure microparticles with masses as high as 1015 Da and to distinguish cancer cells from normal cells. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
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收藏
页码：3865 / 3869
页数：5
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