Molecular mechanisms of anticancer activity of natural dietetic products

被引：74
作者：
Colic, M
Pavelic, K
机构：
[1] Rudjer Boskovic Inst, Div Mol Med, Zagreb 10000, Croatia
[2] Molecutec Corp, R&D Div, Goleta, CA 93117 USA
来源：
JOURNAL OF MOLECULAR MEDICINE-JMM | 2000年 / 78卷 / 06期
关键词：
dietetic supplements; mechanism of anticancer activity;
D O I：
10.1007/s001090000121
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The efficiency of dietetic supplements in cancer prevention and treatment is a popular and controversial subject of research. New in vitro and in vivo research results indicate that some dietetic supplements do indeed show anticancer activity. The strongest anticancer action has been demonstrated by natural compounds with multifunctional activity. For instance, antioxidants, which also bind to and modulate the activity of protein kinases involved in signal transduction cascades show both cytostatic and cytotoxic activity towards cancer cells. Other activities such as angiogenesis inhibition, nitric oxide synthase inhibition, ana pro-oxidants production have also been observed. Catechins and polyphenols from plant extracts such as green tea show the strongest anticancer activity. The initial clinical trials with some flavonoid molecules are already underway.
引用
收藏
页码：333 / 336
页数：4
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