Direct Observation of C-H Cyclopalladation at Tertiary Positions Enabled by an Exo-Directing Group

被引：30

作者：

Ren, Zhi ^{[1
]}

Dong, Guangbin ^{[1
]}

机构：

[1] Univ Texas Austin, Dept Chem, Austin, TX 78712 USA

来源：

ORGANOMETALLICS | 2016年 / 35卷 / 08期

关键词：

CATALYZED DIRECT ARYLATION; QUATERNARY CARBON CENTERS; INSERTION REACTIONS; PALLADIUM; BOND; FUNCTIONALIZATION; ACTIVATION; REACTIVITY; CYCLOPROPANES; ME;

D O I：

10.1021/acs.organomet.6b00185

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Here we describe the first preparation of tertiary alkyl palladium complexes via C-H activation. Enabled by an exo-type oxime directing group, cyclopalladation occurred smoothly at the bridgehead position. Treatment of the resulting complex with iodine led to C-H iodination at the methine carbon. This study provides important mechanistic information for palladium-catalyzed functionalization of methine C-H bonds.

引用

收藏

页码：1057 / 1059

页数：3

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