Biopsy-proven liver cirrhosis in young children: A 10-year cohort study
被引:3
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作者:
Dong, Yi
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Chinese Peoples Liberat Army Gen Hosp, Beijing Hosp 302, Med Ctr 5, 100 West Fourth Ring Middle Rd, Beijing 100039, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Beijing Hosp 302, Med Ctr 5, 100 West Fourth Ring Middle Rd, Beijing 100039, Peoples R China
Dong, Yi
[1
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Li, Aiqin
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Chinese Peoples Liberat Army Gen Hosp, Beijing Hosp 302, Med Ctr 5, 100 West Fourth Ring Middle Rd, Beijing 100039, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Beijing Hosp 302, Med Ctr 5, 100 West Fourth Ring Middle Rd, Beijing 100039, Peoples R China
Li, Aiqin
[1
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Zhu, Shishu
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Chinese Peoples Liberat Army Gen Hosp, Beijing Hosp 302, Med Ctr 5, 100 West Fourth Ring Middle Rd, Beijing 100039, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Beijing Hosp 302, Med Ctr 5, 100 West Fourth Ring Middle Rd, Beijing 100039, Peoples R China
Zhu, Shishu
[1
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Chen, Weibin
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Beijing Yunsheng Sci & Technol Co Ltd, Beijing, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Beijing Hosp 302, Med Ctr 5, 100 West Fourth Ring Middle Rd, Beijing 100039, Peoples R China
Chen, Weibin
[2
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Li, Meina
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Second Mil Med Univ, Dept Hlth Serv, Shanghai, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Beijing Hosp 302, Med Ctr 5, 100 West Fourth Ring Middle Rd, Beijing 100039, Peoples R China
Li, Meina
[3
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Zhao, Pan
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Chinese Peoples Liberat Army Gen Hosp, Beijing Hosp 302, Med Ctr 5, 100 West Fourth Ring Middle Rd, Beijing 100039, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Beijing Hosp 302, Med Ctr 5, 100 West Fourth Ring Middle Rd, Beijing 100039, Peoples R China
Zhao, Pan
[1
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机构:
[1] Chinese Peoples Liberat Army Gen Hosp, Beijing Hosp 302, Med Ctr 5, 100 West Fourth Ring Middle Rd, Beijing 100039, Peoples R China
[2] Beijing Yunsheng Sci & Technol Co Ltd, Beijing, Peoples R China
[3] Second Mil Med Univ, Dept Hlth Serv, Shanghai, Peoples R China
Young children with liver cirrhosis have a significantly high risk of mortality. However, there are few studies regarding early childhood-onset cirrhosis. This study aims to explore the causes, clinical findings and prognosis of biopsy-proven cirrhosis in infants, toddlers and preschoolers. We enroled young children with biopsy-proven cirrhosis from January 2010. Till January 2020, the study has been going on for 10 years. A total of 139 cirrhotic children were enrolled, including 87 boys and 52 girls. The median age at initially histological diagnosis of cirrhosis was 2 years old (range: 1 month-6 years). Sixty-two patients reported yellowish discoloration of sclera and/or skin as an initial symptom. Ninety-three patients had definite aetiologies while 46 had indeterminate causes. Among the confirmed cases, 31 had hepatitis B virus (HBV) infection, accounting for 33.3%. Subsequently, glycogen storage disease was diagnosed in 16 cases and Wilson disease in 14 cases. In these patients with HBV infection, nine finally achieved hepatitis B surface antigen (HBsAg) loss (29.0%) after effective antiviral therapy during the follow-up. Logistic regression revealed that baseline alanine aminotransferase (odds ratio 1.008, p = 0.028) was the independent predictor of HBsAg loss. Furthermore, one patient who underwent second biopsies showed histological reverse. HBV infection is an important cause of paediatric cirrhosis in our study. The pathogenesis of HBV-related cirrhosis in early childhood deserves further studies.
机构:Kaohsiung Chang Gung Mem Hosp, Dept Ophthalmol, 123 Da Pi Rd, Kaohsiung 88301, Taiwan
Chuang, Meng-Ni
Fang, Po-Chiung
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机构:Kaohsiung Chang Gung Mem Hosp, Dept Ophthalmol, 123 Da Pi Rd, Kaohsiung 88301, Taiwan
Fang, Po-Chiung
Wu, Pei-Chang
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Kaohsiung Chang Gung Mem Hosp, Dept Ophthalmol, 123 Da Pi Rd, Kaohsiung 88301, TaiwanKaohsiung Chang Gung Mem Hosp, Dept Ophthalmol, 123 Da Pi Rd, Kaohsiung 88301, Taiwan
机构:
Univ Fed Santa Maria, Post Grad Program Dent Sci, Santa Maria, BrazilUniv Fed Santa Maria, Post Grad Program Dent Sci, Santa Maria, Brazil
Godois, Leonardo da Silva
Knorst, Jessica Klockner
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Univ Fed Santa Maria, Sch Dent, Dept Stomatol, Santa Maria, BrazilUniv Fed Santa Maria, Post Grad Program Dent Sci, Santa Maria, Brazil
Knorst, Jessica Klockner
Noronha, Thais Gioda
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Univ Fed Santa Maria, Post Grad Program Dent Sci, Santa Maria, BrazilUniv Fed Santa Maria, Post Grad Program Dent Sci, Santa Maria, Brazil
Noronha, Thais Gioda
Emmanuelli, Bruno
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Univ Fed Santa Maria, Sch Dent, Dept Stomatol, Santa Maria, BrazilUniv Fed Santa Maria, Post Grad Program Dent Sci, Santa Maria, Brazil
Emmanuelli, Bruno
Ardenghi, Thiago Machado
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Univ Fed Santa Maria, Sch Dent, Dept Stomatol, Santa Maria, BrazilUniv Fed Santa Maria, Post Grad Program Dent Sci, Santa Maria, Brazil
Ardenghi, Thiago Machado
Tomazoni, Fernanda
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Univ Fed Santa Maria, Sch Dent, Dept Stomatol, Santa Maria, Brazil
Univ Fed Santa Maria, Dept Estomatol, Fac Odontol, Ave Roraima 1000,Cidade Univ 26F, BR-97015372 Santa Maria, RS, BrazilUniv Fed Santa Maria, Post Grad Program Dent Sci, Santa Maria, Brazil
机构:
Univ Lyon 1, Pediat Hematol & Oncol Inst, Hosp Civils Lyon, F-69008 Lyon, France
Univ Claude Bernard Lyon 1, Fac Med Lyon Est, F-69008 Lyon, FranceCtr Leon Berard, Pharm Dept, F-69008 Lyon, France
Bertrand, Yves
Philippe, Michael
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Ctr Leon Berard, Pharm Dept, F-69008 Lyon, France
Univ Lyon 1, Pediat Hematol & Oncol Inst, Hosp Civils Lyon, F-69008 Lyon, FranceCtr Leon Berard, Pharm Dept, F-69008 Lyon, France
Philippe, Michael
Domenech, Carine
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Univ Lyon 1, Pediat Hematol & Oncol Inst, Hosp Civils Lyon, F-69008 Lyon, France
Univ Claude Bernard Lyon 1, Fac Med & Maieut Charles Merieux Lyon Sud, F-69921 Lyon, France
Univ Lyon 1, Int Ctr Res Infectiol, INSERM 1111, CNRS UMR 5308, F-69007 Lyon, FranceCtr Leon Berard, Pharm Dept, F-69008 Lyon, France
机构:
Childrens Hosp Montefiore, Div Adolescent Med, 2415 Bainbridge Ave, Bronx, NY 10467 USA
Hackensack Univ, Joseph M Sanzari Childrens Hosp, Med Ctr, Hackensack, NJ USAChildrens Hosp Montefiore, Div Adolescent Med, 2415 Bainbridge Ave, Bronx, NY 10467 USA
Al-Husayni, Noor
Maslyanskaya, Sofya
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Childrens Hosp Montefiore, Div Adolescent Med, 2415 Bainbridge Ave, Bronx, NY 10467 USA
Albert Einstein Coll Med, Pediat, Bronx, NY USAChildrens Hosp Montefiore, Div Adolescent Med, 2415 Bainbridge Ave, Bronx, NY 10467 USA
Maslyanskaya, Sofya
Rubinstein, Tamar B.
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机构:
Albert Einstein Coll Med, Pediat, Bronx, NY USA
Childrens Hosp Montefiore, Div Pediat Rheumatol, Bronx, NY 10467 USAChildrens Hosp Montefiore, Div Adolescent Med, 2415 Bainbridge Ave, Bronx, NY 10467 USA
Rubinstein, Tamar B.
Coupey, Susan M.
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Childrens Hosp Montefiore, Div Adolescent Med, 2415 Bainbridge Ave, Bronx, NY 10467 USA
Albert Einstein Coll Med, Pediat, Bronx, NY USAChildrens Hosp Montefiore, Div Adolescent Med, 2415 Bainbridge Ave, Bronx, NY 10467 USA