Stem cells for tissue engineered vascular bypass grafts

被引:8
作者
Askari, Forough [1 ]
Solouk, Atefeh [1 ]
Shafieian, Mehdi [1 ]
Seifalian, Alexander M. [2 ,3 ]
机构
[1] Amirkabir Univ Technol, Dept Biomed Engn, Tehran, Iran
[2] UCL, Ctr Nanotechnol & Regenerat Med, London, England
[3] Royal Free Hampstead Natl Hlth Serv Trust Hosp, London, England
关键词
Artery; blood vessels; scaffold; stem cells; tissue engineering; vascular bypass grafts; BLOOD-VESSELS; SMOOTH-MUSCLE; PROGENITOR CELLS; IN-VIVO; MODEL; REGENERATION; FIBROBLASTS; COLLAGEN; CULTURE; DIFFERENTIATION;
D O I
10.1080/21691401.2016.1198366
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Despite great advances in tissue engineering, there have been very few reports on the successful clinical use of small-diameter tissue-engineered vascular grafts (TEVGs). Small-diameter (<6 mm internal diameter) is considered as unmet clinical need. This review critically examines the role of stem cells that have been proposed and used in development of TEVGs, and assesses the viability of such graft to clinical pathway. With over 20 years of expertise in development of bypass graft and a number of grafts under clinical trial, this team will offer potential areas for future research that may help improve the current state-of-the-art technology.
引用
收藏
页码:999 / 1010
页数:12
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