Chiral Aryliodine-Catalyzed Asymmetric Oxidative C-N Bond Formation via Desymmetrization Strategy

被引：36

作者：

Ding, Qiang ^{[1
,2
]}

He, Huan ^{[1
,2
,3
]}

Cai, Qian ^{[1
,2
]}

机构：

[1] Jinan Univ, Coll Pharm, 601 Huangpu Ave West, Guangzhou 510632, Guangdong, Peoples R China

[2] Hebei Univ Sci & Technol, Guangzhou City Key Lab Precis Chem Drug Dev, Shijiazhuang 050018, Hebei, Peoples R China

[3] Hebei Univ Sci & Technol, Coll Chem & Pharmaceut Engn, Shijiazhuang 050018, Hebei, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 15期

关键词：

HYPERVALENT IODINE OXIDATION; ENANTIOSELECTIVE DESYMMETRIZATION; H AMINATION; DEAROMATIZATION; SPIROLACTONIZATION; REAGENTS; CYCLIZATION; CHEMISTRY; ARENES; ACID;

D O I：

10.1021/acs.orglett.8b01849

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An asymmetric oxidative C-N bond-forming reaction is developed using a chiral diiodospirobiindane derivative as the catalyst and mCPBA as a terminal oxidant. The protocol is based on an asymmetric desymmetrization strategy and affords lactams or spirolactams according to the different substituents on the substrates. The products are obtained in good yields and moderate to high enantioselectivities.

引用

页码：4554 / 4557

页数：4

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