Pathophysiology, diagnosis, and management of hepatic encephalopathy

被引：10
作者：
Sheasgreen, Christopher [1 ]
Lu, Lucy [1 ]
Patel, Ameen [1 ]
机构：
[1] McMaster Univ, Dept Med, Hamilton, ON, Canada
来源：
INFLAMMOPHARMACOLOGY | 2014年 / 22卷 / 06期
关键词：
Hepatic encephalopathy; Ammonia; Lactulose; Antibiotics; PORTAL-SYSTEMIC ENCEPHALOPATHY; RANDOMIZED CONTROLLED-TRIAL; NECROSIS-FACTOR-ALPHA; DOUBLE-BLIND; LIVER-DISEASE; CIRRHOTIC-PATIENTS; ALBUMIN DIALYSIS; AMMONIA LEVELS; SECONDARY PROPHYLAXIS; NITROGEN-METABOLISM;
D O I：
10.1007/s10787-014-0217-9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Hepatic encephalopathy (HE) is a common complication of cirrhosis of the liver. It is also extremely debilitating, with an untreated 3-year survival of only 23 %. While the exact pathophysiology of HE has yet to be elucidated, a number of contributing factors have been described. Abnormal levels and altered metabolism of ammonia play a central role. Recently, inflammation has also been identified as a contributor to HE. Improved understanding of the pathophysiology of HE is crucial, as current therapy centers on reduction of the body's ammonia load. Lactulose is the first-line therapy for HE, with some antibiotics recently showing promise for improved outcomes in patients with HE. The role of anti-inflammatory therapies has yet to be evaluated.
引用
收藏
页码：319 / 326
页数：8
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