A two-holed story: Structural secrets about CIC proteins become unraveled?

被引：10
作者：
Babini, E [1 ]
Pusch, M [1 ]
机构：
[1] CNR, Ist Biofis, I-16149 Genoa, Italy
来源：
PHYSIOLOGY | 2004年 / 19卷
关键词：
D O I：
10.1152/physiol.00019.2004
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
CIC Cl- channels are found in almost all organisms, ranging from bacteria to mammals, in which nine Cl- channels belonging to the CIC family have been identified. The biophysical properties and physiological functions of CIC Cl- channels have been extensively reviewed. In this short review, we will focus on recent results obtained on the X-ray structure and functional properties of the prokaryotic CIC-ec1 protein and some results obtained on the role of the cytoplasmic COOH terminus of mammalian CICs.
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页码：293 / 299
页数：7
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[21]   Molecular structure and physiological function of chloride channels [J].
Jentsch, TJ ;
Stein, V ;
Weinreich, F ;
Zdebik, AA .
PHYSIOLOGICAL REVIEWS, 2002, 82 (02) :503-568
[22]   Loss of the CIC-7 chloride channel leads to osteopetrosis in mice and man [J].
Kornak, U ;
Kasper, D ;
Bösl, MR ;
Kaiser, E ;
Schweizer, M ;
Schulz, A ;
Friedrich, W ;
Delling, G ;
Jentsch, TJ .
CELL, 2001, 104 (02) :205-215
[23]   Biophysical properties of ClC-3 differentiate it from swelling-activated chloride channels in Chinese hamster ovary-K1 cells [J].
Li, XH ;
Shimada, K ;
Showalter, LA ;
Weinman, SA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (46) :35994-35998
[24]   Two physically distinct pores in the dimeric CIC-0 chloride channel [J].
Ludewig, U ;
Pusch, M ;
Jentsch, TJ .
NATURE, 1996, 383 (6598) :340-343
[25]   Formation of CLC-0 chloride channels from separated transmembrane and cytoplasmic domains [J].
Maduke, M ;
Williams, C ;
Miller, C .
BIOCHEMISTRY, 1998, 37 (05) :1315-1321
[26]   High-level expression, functional reconstitution, and quaternary structure of a prokaryotic ClC-type chloride channel [J].
Maduke, M ;
Pheasant, DJ ;
Miller, C .
JOURNAL OF GENERAL PHYSIOLOGY, 1999, 114 (05) :713-722
[27]   Homodimeric architecture of a CIC-type chloride ion channel [J].
Middleton, RE ;
Pheasant, DJ ;
Miller, C .
NATURE, 1996, 383 (6598) :337-340
[28]   OPEN-STATE SUBSTRUCTURE OF SINGLE CHLORIDE CHANNELS FROM TORPEDO ELECTROPLAX [J].
MILLER, C .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1982, 299 (1097) :401-411
[29]   Anion pathway and potential energy profiles along curvilinear bacterial ClC Cl- pores:: Electrostatic effects of charged residues [J].
Miloshevsky, GV ;
Jordan, PC .
BIOPHYSICAL JOURNAL, 2004, 86 (02) :825-835
[30]  
Mindell JA, 2001, GENOME BIOL, V2
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