A two-holed story: Structural secrets about CIC proteins become unraveled?

被引：10
作者：
Babini, E [1 ]
Pusch, M [1 ]
机构：
[1] CNR, Ist Biofis, I-16149 Genoa, Italy
来源：
PHYSIOLOGY | 2004年 / 19卷
关键词：
D O I：
10.1152/physiol.00019.2004
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
CIC Cl- channels are found in almost all organisms, ranging from bacteria to mammals, in which nine Cl- channels belonging to the CIC family have been identified. The biophysical properties and physiological functions of CIC Cl- channels have been extensively reviewed. In this short review, we will focus on recent results obtained on the X-ray structure and functional properties of the prokaryotic CIC-ec1 protein and some results obtained on the role of the cytoplasmic COOH terminus of mammalian CICs.
引用
收藏
页码：293 / 299
页数：7
相关论文
共 50 条
[1]   Ionic currents mediated by a prokaryotic homologue of CLC Cl- channels [J].
Accardi, A ;
Kolmakova-Partensky, L ;
Williams, C ;
Miller, C .
JOURNAL OF GENERAL PHYSIOLOGY, 2004, 123 (02) :109-119
[2]   Conformational changes in the pore of CLC-0 [J].
Accardi, A ;
Pusch, M .
JOURNAL OF GENERAL PHYSIOLOGY, 2003, 122 (03) :277-293
[3]   Secondary active transport mediated by a prokaryotic homologue of ClC Cl- channels [J].
Accardi, A ;
Miller, C .
NATURE, 2004, 427 (6977) :803-807
[4]   Secretion and cell volume regulation by salivary acinar cells from mice lacking expression of the Clcn3 Cl- channel gene [J].
Arreola, J ;
Begenisich, T ;
Nehrke, K ;
Nguyen, HV ;
Park, K ;
Richardson, L ;
Yang, BL ;
Schutte, BC ;
Lamb, FS ;
Melvin, JE .
JOURNAL OF PHYSIOLOGY-LONDON, 2002, 545 (01) :207-216
[5]   Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2Cl- channel disruption [J].
Bösl, MR ;
Stein, V ;
Hübner, C ;
Zdebik, AA ;
Jordt, SE ;
Mukhopadhyay, AK ;
Davidoff, MS ;
Holstein, AF ;
Jentsch, TJ .
EMBO JOURNAL, 2001, 20 (06) :1289-1299
[6]   ClC-6 and ClC-7 are two novel broadly expressed members of the CLC chloride channel family [J].
Brandt, S ;
Jentsch, TJ .
FEBS LETTERS, 1995, 377 (01) :15-20
[7]   Different fast-gate regulation by external Cl- and H+ of the muscle-type CIC chloride channels [J].
Chen, MF ;
Chen, TY .
JOURNAL OF GENERAL PHYSIOLOGY, 2001, 118 (01) :23-32
[8]   The structure of the potassium channel:: Molecular basis of K+ conduction and selectivity [J].
Doyle, DA ;
Cabral, JM ;
Pfuetzner, RA ;
Kuo, AL ;
Gulbis, JM ;
Cohen, SL ;
Chait, BT ;
MacKinnon, R .
SCIENCE, 1998, 280 (5360) :69-77
[9]   X-ray structure of a CIC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity [J].
Dutzler, R ;
Campbell, EB ;
Cadene, M ;
Chait, BT ;
MacKinnon, R .
NATURE, 2002, 415 (6869) :287-294
[10]   Gating the selectivity filter in ClC chloride channels [J].
Dutzler, R ;
Campbell, EB ;
MacKinnon, R .
SCIENCE, 2003, 300 (5616) :108-112
12345