Parathyroid Hormone: Is There a Role in Fracture Healing?

被引：9

作者：

Della Rocca, Gregory J. ^{[1
]}

Crist, Brett D. ^{[1
]}

Murtha, Yvonne M. ^{[1
]}

机构：

[1] Univ Missouri, Dept Orthopaed Surg, Columbia, MO 65212 USA

来源：

JOURNAL OF ORTHOPAEDIC TRAUMA | 2010年 / 24卷

关键词：

parathyroid hormone; fracture healing; calcium metabolism; fracture nonunion; INTENSITY PULSED ULTRASOUND; HUMAN PARATHYROID-HORMONE-(1-34); MODEL; ENHANCEMENT; RABBITS; GROWTH; PTH;

D O I：

10.1097/BOT.0b013e3181cde5d1

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Parathyroid hormone is a well-known regulator of calcium metabolism in the body. It binds to osteoblasts and assists in the regulation of bone turnover. Changes in parathyroid hormone levels have been documented in pathologic states such as osteoporosis, and fluxes are also noted during healing of fractures. Because fracture healing requires time and is sometimes unreliable, a search for fracture-healing adjuvants that accelerate the healing rate and improve reliability of healing is compelling. Parathyroid hormone, as a systemic mediator of calcium and bone metabolism, is a good candidate. Much research has been accomplished in animal models examining the role of parathyroid hormone in fracture healing. Although further research is required, especially in human fracture patients, early indicators are that parathyroid hormone may play a role in accelerating fracture healing in healthy patients and in reducing rates of fracture nonunion in compromised patients or tissue beds.

引用

页码：S31 / S35

页数：5

共 32 条

[1] Enhancement of experimental fracture-healing by systemic administration of recombinant human parathyroid hormone (PTH 1-34) [J].

Alkhiary, YM ;

Gerstenfeld, LC ;

Krall, E ;

Westmore, M ;

Sato, M ;

Mitlak, BH ;

Einhorn, TA .

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2005, 87A (04) :731-741

[2] Intermittent parathyroid hormone (1-34) treatment increases callus formation and mechanical strength of healing rat fractures [J].

Andreassen, TT ;

Ejersted, C ;

Oxlund, H .

JOURNAL OF BONE AND MINERAL RESEARCH, 1999, 14 (06) :960-968

[3] Stimulation of fracture-healing with systemic intermittent parathyroid hormone treatment [J].

Barnes, George L. ;

Kakar, Sanjeev ;

Vora, Siddarth ;

Morgan, Elise E. ;

Gerstenfeld, Louis C. ;

Einhorn, Thomas A. .

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2008, 90A :120-127

[4] Parathyroid hormone-related protein analog R8-66271 is an effective therapy for impaired bone healing in rabbits on corticosteroid therapy [J].

Bostrom, MPG ;

Gamradt, SC ;

Asnis, P ;

Vickery, BH ;

Hill, E ;

Avnur, Z ;

Waters, RV .

BONE, 2000, 26 (05) :437-442

[5] Metabolic and endocrine abnormalities in patients with nonunions [J].

Brinker, Mark R. ;

O'Connor, Daniel P. ;

Monla, Yomna T. ;

Earthman, Thomas P. .

JOURNAL OF ORTHOPAEDIC TRAUMA, 2007, 21 (08) :557-570

[6] Combination of local and systemic parathyroid hormone enhances bone regeneration [J].

Chen, H ;

Frankenburg, EP ;

Goldstein, SA ;

McCauley, LK .

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2003, (416) :291-302

[7]

Friedlaender GE, 2001, J BONE JOINT SURG AM, V83A, pS151

[8] Role of parathyroid hormone in the mechanosensitivity of fracture healing [J].

Gardner, Michael J. ;

van der Meulen, Marjolein C. H. ;

Carson, Joshua ;

Zelken, Jonathan ;

Ricciardi, Benjamin F. ;

Wright, Timothy A. ;

Lane, Joseph M. ;

Bostrom, Mathias P. .

JOURNAL OF ORTHOPAEDIC RESEARCH, 2007, 25 (11) :1474-1480

[9] Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures -: A prospective, controlled, randomized study of four hundred and fifty patients [J].

Govender, S ;

Csimma, C ;

Genant, HK ;

Valentin-Opran, A ;

Amit, Y ;

Arbel, R ;

Aro, H ;

Atar, D ;

Bishay, M ;

Börner, MG ;

Chiron, P ;

Choong, P ;

Cinats, J ;

Courtenay, B ;

Feibel, R ;

Geulette, B ;

Gravel, C ;

Haas, N ;

Raschke, M ;

Hammacher, E ;

van der Velde, D ;

Hardy, P ;

Holt, M ;

Josten, C ;

Ketterl, RL ;

Lindeque, B ;

Lob, G ;

Mathevon, H ;

Mccoy, G ;

Marsh, D ;

Miller, R ;

Munting, E ;

Oevre, S ;

Nordsletten, L ;

Patel, A ;

Pohl, A ;

Rennie, W ;

Reynders, P ;

Rommens, PM ;

Rondia, J ;

Rossouw, WC ;

Daneel, PJ ;

Ruff, S ;

Rüter, A ;

Santavirta, S ;

Schildhauer, TA ;

Gekle, C ;

Schnettler, R ;

Segal, D ;

Seiler, H .

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2002, 84A (12) :2123-2134

[10] EFFECTS OF GLUCOCORTICOIDS ON SKELETAL GROWTH IN RABBITS EVALUATED BY DUAL-PHOTON ABSORPTIOMETRY, MICROSCOPIC CONNECTIVITY AND VERTEBRAL COMPRESSIVE STRENGTH [J].

GRARDEL, B ;

SUTTER, B ;

FLAUTRE, B ;

VIGUIER, E ;

LAVASTE, F ;

HARDOUIN, P .

OSTEOPOROSIS INTERNATIONAL, 1994, 4 (04) :204-210

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