Synthesis of a theranostic agent: radioiodinated PEGylated PLGA-indocyanine capsules and in vitro determination of their bioaffinity on ovarian, cervical and breast cancer cells

被引：6

作者：

Akman, Levent ^{[1
]}

Muftuler, Fazilet Zumrut Biber ^{[2
]}

Bilgi, Ahmet ^{[1
]}

Kilcar, Ayfer Yurt ^{[2
]}

Gokulu, Sevki Goksun ^{[1
]}

Medine, Emin Ilker ^{[2
]}

Terek, Mustafa Cosan ^{[1
]}

机构：

[1] Ege Univ, Fac Med, Dept Obstet & Gynecol, TR-35100 Izmir, Turkey

[2] Ege Univ, Inst Nucl Sci, Dept Nucl Applicat, TR-35100 Izmir, Turkey

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2016年 / 308卷 / 02期

关键词：

Indocyanine; Encapsulation; (131) I; In vitro cell culture studies; Paclitaxel; GREEN NANOPARTICLES; DRUG; BIODISTRIBUTION; DELIVERY; PEG; GLUCURONIDE; PACLITAXEL; PROTEIN; NODE;

D O I：

10.1007/s10967-015-4472-z

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The aim of current study is to synthesize a theranostic (multi-functional) agent, which is targeted on ovary, cervical and breast cancer types with diagnosis and treatment potential and to determine its bioaffinity by using in vitro methods. In conclusion; the designed compound (IPPP), which has fluorescence capability (from Indocyanine), encapsulated structure (with PEGylated PLGA), included an anticancer drug (Paclitaxel) for targeting and radionuclidic tracer (I-131) content for tracing, has bioaffinity and promise for diagnosis and therapy on ovarian, cervical and breast cancer cell lines.

引用

页码：659 / 670

页数：12

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