HIV-1 Virological Synapse is not Simply a Copycat of the Immunological Synapse

被引：44

作者：

Vasiliver-Shamis, Gaia ^{[1
]}

Dustin, Michael L. ^{[1
]}

Hioe, Catarina E. ^{[2
]}

机构：

[1] NYU, Sch Med, Skirball Inst Biomol Med, Martin & Helen Kimmel Ctr Biol & Med,Program Mol, New York, NY 10016 USA

[2] NYU, Sch Med, Dept Pathol, Vet Affairs New York Harbor Healthcare Syst, New York, NY 10010 USA

来源：

VIRUSES-BASEL | 2010年 / 2卷 / 05期

关键词：

HIV-1; HIV; virological synapse; immunological synapse; HIV envelope; gp120; T cell receptor; CD4 T lymphocyte; HUMAN-IMMUNODEFICIENCY-VIRUS; T-CELL-RECEPTOR; MICROTUBULE-ORGANIZING CENTER; FOCAL ADHESION KINASE; DENDRITIC CELLS; TYPE-1; INFECTION; MEDIATED APOPTOSIS; GENE-EXPRESSION; TARGET-CELLS; KILLER-CELLS;

D O I：

10.3390/v2051239

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The virological synapse (VS) is a tight adhesive junction between an HIV-infected cell and an uninfected target cell, across which virus can be efficiently transferred from cell to cell in the absence of cell-cell fusion. The VS has been postulated to resemble, in its morphology, the well-studied immunological synapse (IS). This review article discusses the structural similarities between IS and VS and the shared T cell receptor (TCR) signaling components that are found in the VS. However, the IS and the VS display distinct kinetics in disassembly and intracellular signaling events, possibly leading to different biological outcomes. Hence, HIV-1 exploits molecular components of IS and TCR signaling machinery to trigger unique changes in cellular morphology, migration, and activation that facilitate its transmission and cell-to-cell spread.

引用

页码：1239 / 1260

页数：22

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