Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity

被引：62
作者：
Xu, Sijin [1 ]
Chen, Shuaipeng [1 ]
Xia, Wenxin [1 ]
Sui, Hong [1 ,2 ,3 ,4 ]
Fu, Xueyan [1 ,2 ,3 ,4 ]
机构：
[1] Ningxia Med Univ, Sch Pharm, Yinchuan 750004, Ningxia, Peoples R China
[2] Ningxia Collaborat Innovat Ctr Reg Characterist T, Yinchuan 750004, Ningxia, Peoples R China
[3] Ningxia Med Univ, Minist Educ, Key Lab Ningxia Ethnomed Modernizat, Yinchuan 750004, Ningxia, Peoples R China
[4] Ningxia Reg Key Lab Integrated Traditional Chines, Yinchuan 750004, Ningxia, Peoples R China
来源：
MOLECULES | 2022年 / 27卷 / 09期
基金：
中国国家自然科学基金;
关键词：
hyperoside; structure; pharmacology; pharmacokinetics; toxicity; review; ISCHEMIA-REPERFUSION INJURY; CANCER CELLS; IN-VITRO; OXIDATIVE STRESS; ANTICANCER ACTIVITY; BUNGEANUM LEAVES; INFLAMMATION; APOPTOSIS; PROTECTS; MECHANISM;
D O I：
10.3390/molecules27093009
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hyperoside is an active ingredient in plants, such as Hypericum monogynum in Hypericaceae, Crataegus pinnatifida in Rosaceae and Polygonum aviculare in Polygonaceae. Its pharmacologic effects include preventing cancer and protecting the brain, neurons, heart, kidneys, lung, blood vessels, bones, joints and liver, among others. Pharmacokinetic analysis of hyperoside has revealed that it mainly accumulates in the kidney. However, long-term application of high-dose hyperoside should be avoided in clinical practice because of its renal toxicity. This review summarises the structure, synthesis, pharmacology, pharmacokinetics and toxicity of hyperoside.
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页数：26
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