The induction of H3K9 methylation by PIWIL4 at the p16Ink4a locus

被引：63

作者：

Sugimoto, Keiki

Kage, Hidenori

Aki, Naomi

Sano, Atsushi

Kitagawa, Hiroshi

Nagase, Takahide

Yatomi, Yutaka

Ohishi, Nobuya

Takai, Daiya

机构：

[1] Tokyo Univ Hosp, Dept Clin Lab, Bunkyo Ku, Tokyo 113, Japan

[2] Tokyo Univ Hosp, Dept Resp Med, Bunkyo Ku, Tokyo 113, Japan

[3] Tokyo Univ Hosp, Dept Gen Thorac Surg, Bunkyo Ku, Tokyo 113, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2007年 / 359卷 / 03期

基金：

日本学术振兴会;

关键词：

PIWI; epigenetics; histone methylation; p16(Ink4a);

D O I：

10.1016/j.bbrc.2007.05.136

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The field of epigenetics has made progress by the identification of the small RNA-mediated epigenetic modification. However, little is known about the key proteins. Here, we report that the human PIWI-like family is a candidate protein that is involved in the pathway responsible for chromatin remodeling. The PIWI-like family proteins, expressed as the Flag-fusion proteins, formed a bulky body and localized to the nuclear periphery. Transient transfection of PIWI-like 4 (PIWIL4), only member of the PIWI-like family that was ubiquitously expressed in human tissues, induced historic H3 lysine 9 methylation at the p16(Ink4a) (CDKN2A) locus. The elevated level of histone methylation resulted in the downregulation of the p16(Ik4a) gene. These results suggest PIWIL4 plays important roles in the chromatin-modifying pathway in human somatic cells. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：497 / 502

页数：6

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