Synthesis of Aminonaphthopyranones and Aminonaphthochromenones by Blaise-Reaction-Initiated Cascade Procedures

被引：8

作者：

He, Yan ^{[1
]}

Zhang, Xinying ^{[1
]}

Fan, Xuesen ^{[1
]}

机构：

[1] Henan Normal Univ, Collaborat Innovat Ctr Henan Prov Green Mfg Fine, Henan Key Lab Environm Pollut Control, Sch Environm,Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 3卷 / 12期

关键词：

aminonaphthochromenones; aminonaphthopyranones; cascade reactions; one-pot reactions; Reformatsky reagents; ONE-POT SYNTHESIS; FUNGUS GUANOMYCES-POLYTHRIX; NAPHTHALENE AMINO ESTERS; REACTION INTERMEDIATE; ASYMMETRIC CATALYSIS; BIARYL LACTONES; TANDEM; LACTONIZATION; DERIVATIVES; ACYLATION;

D O I：

10.1002/ajoc.201402173

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient one-pot synthesis of aminonaphthopyranones through the tandem reaction of 2-(4-hydroxybut-1-ynyl) benzonitriles with Reformatsky reagents has been developed. Using a similar strategy, aminonaphthochromenones were obtained smoothly starting from 2-[(2-hydroxyphenyl) ethynyl] benzonitriles. Furthermore, by taking advantage of the versatile reactivity of the amino group, structural manipulations of aminonaphthopyranone were readily undertaken to give naphthopyranone, 10-hydroxynaphthopyranone and a functionalized 1,1 '-binaphthyl of potential interest for synthetic and medicinal chemistry studies.

引用

页码：1284 / 1291

页数：8

共 53 条

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[Anonymous], 2014, ANGEW CHEM-GER EDIT

[2]

Bode S. E., 2007, ANGEW CHEM, V119, P6020

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