Drug therapy of experimental tuberculosis (TB): Improved outcome by combining SQ109, a new diamine antibiotic, with existing TB drugs

被引：114
作者：
Nikonenko, Boris V.
Protopopova, Marina
Sarnala, Rowena
Einck, Leo
Nacy, Carol A.
机构：
[1] Sequella Inc, Rockville, MD 20850 USA
[2] Cent Res Inst TB, Moscow 107564, Russia
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 04期
关键词：
D O I：
10.1128/AAC.01326-06
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Substitution of the new diamine antibiotic SQ109 for ethambutol in a mouse model of chronic tuberculosis (TB) improved efficacy of combination drug therapy with first-line TB drugs rifampin and isoniazid, with or without pyrazinamide: at 8 weeks, lung bacteria were 1.5 log(10) lower in SQ109-containing regimens.
引用
收藏
页码：1563 / 1565
页数：3
相关论文
共 17 条
[1]   A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis [J].
Andries, K ;
Verhasselt, P ;
Guillemont, J ;
Göhlmann, HWH ;
Neefs, JM ;
Winkler, H ;
Van Gestel, J ;
Timmerman, P ;
Zhu, M ;
Lee, E ;
Williams, P ;
de Chaffoy, D ;
Huitric, E ;
Hoffner, S ;
Cambau, E ;
Truffot-Pernot, C ;
Lounis, N ;
Jarlier, V .
SCIENCE, 2005, 307 (5707) :223-227
[2]   Identification of new diamine scaffolds with activity against Mycobacterium tuberculosis [J].
Bogatcheva, Elena ;
Hanrahan, Colleen ;
Nikonenko, Boris ;
Samala, Rowena ;
Chen, Ping ;
Gearhart, Jacqueline ;
Barbosa, Francis ;
Einck, Leo ;
Nacy, Carol A. ;
Protopopova, Marina .
JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (11) :3045-3048
[3]   The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism -: Novel insights into drug mechanisms of action [J].
Boshoff, HIM ;
Myers, TG ;
Copp, BR ;
McNeil, MR ;
Wilson, MA ;
Barry, CE .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (38) :40174-40184
[4]   Synergistic interactions of SQ109, a new ethylene diamine, with front-line antitubercular drugs in vitro [J].
Chen, Ping ;
Gearhart, Jackie ;
Protopopova, Marina ;
Einck, Leo ;
Nacy, Carol A. .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2006, 58 (02) :332-337
[5]   In vitro and in vivo activities of moxifloxacin and clinafloxacin against Mycobacterium tuberculosis [J].
Ji, BH ;
Lounis, N ;
Maslo, C ;
Truffot-Pernot, C ;
Bonnafous, P ;
Grosset, J .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (08) :2066-2069
[6]   Pharmacodynamics and pharmacokinetics of SQ109, a new diamine-based antitubercular drug [J].
Jia, J ;
Tomaszewski, JE ;
Hanrahan, C ;
Coward, L ;
Noker, P ;
Gorman, G ;
Nikonenko, B ;
Protopopova, M .
BRITISH JOURNAL OF PHARMACOLOGY, 2005, 144 (01) :80-87
[7]   Pharmacoproteomic effects of isoniazid, ethambutol, and N-geranyl-N′-(2-adamantyl)ethane-1,2-diamine (SQ109) on Mycobacterium tuberculosis H37Rv [J].
Jia, L ;
Coward, L ;
Gorman, GS ;
Noker, PE ;
Tomaszewski, JE .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2005, 315 (02) :905-911
[8]   Simultaneous estimation of pharmacokinetic properties in mice of three anti-tubercular ethambutol analogs obtained from combinatorial lead optimization [J].
Jia, L ;
Tomaszewski, JE ;
Noker, PE ;
Gorman, GS ;
Glaze, E ;
Protopopova, M .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2005, 37 (04) :793-799
[9]   Low-dose aerosol infection model for testing drugs for efficacy against Lycobacterium tuberculosis [J].
Kelly, BP ;
Furney, SK ;
Jessen, MT ;
Orme, IM .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (12) :2809-2812
[10]   Combinatorial lead optimization of [1,2]-diamines based on ethambutol as potential antituberculosis preclinical candidates [J].
Lee, RE ;
Protopopova, M ;
Crooks, E ;
Slayden, RA ;
Terrot, M ;
Barry, CE .
JOURNAL OF COMBINATORIAL CHEMISTRY, 2003, 5 (02) :172-187
12