Effect of α-tocopherol on the oxidative modification of apolipoprotein e in human very-low-density lipoprotein

被引：3

作者：

Arai, H

Uchida, K

Fukunaga, K

Nagasaka, Y

Mohri, S

Furumoto, H

Kuramitsu, Y

Nakamura, K ^{[1
]}

机构：

[1] Yamaguchi Univ, Sch Med, Dept Biochem & Biomol Recognit, Nagoya, Aichi 7558505, Japan

[2] Nagoya Univ, Sch Agr Sci, Lab Food & Biodynam, Nagoya, Aichi 4648601, Japan

[3] Kansai Med Univ, Dept Publ Hlth, Moriguchi, Osaka 5708506, Japan

[4] Yamaguchi Prefectural Univ, Dept Nutr, Yamaguchi 7538502, Japan

[5] Miyagi Prefectural Govt, Ind Technol Inst, Sendai, Miyagi 9813206, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2003年 / 67卷 / 02期

关键词：

apolipoprotein E; oxidation; alpha-tocopherol; very-low-density lipoprotein;

D O I：

10.1271/bbb.67.402

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The oxidative modification of apolipoprotein (apo) E and lipid peroxidation in human very-low-density lipoprotein (VLDL) induced by peroxynitrite and cupric ions in vitro were strongly suppressed by enrichment with a-tocopherol (alpha-Toc; 170 mum). alpha-Toc also suppressed the decrease in the heparin-binding activity of apoE in the VLDL oxidation. These results suggest that alpha-Toc protected apoE in VLDL from oxidative stress.

引用

页码：402 / 405

页数：4

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