MgCl2 catalyzed one-pot synthesis of 2-hydroxy-3-((5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(phenyl)methyl)naphthalene-1,4-dione derivatives in EG

被引：26

作者：

Fu, Zhijie ^{[1
]}

Qian, Kai ^{[1
]}

Li, Sijun ^{[1
]}

Shen, Tianhua ^{[1
]}

Song, Qingbao ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China

来源：

TETRAHEDRON LETTERS | 2016年 / 57卷 / 10期

基金：

美国国家科学基金会;

关键词：

2-Hydroxy-3-((5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(phenyl)methyl)naphthalene-1,4-dione derivatives; One-pot; MgCl2; Ethylene glycol; MULTICOMPONENT REACTIONS; ORGANIC-SYNTHESIS; GREEN;

D O I：

10.1016/j.tetlet.2016.01.089

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A green and convenient synthetic method has been described for the synthesis of 2-hydroxy-3-((5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(phenyl)methyl)naphthalene-1,4-dione derivatives by a one-pot, four-component reaction of aromatic aldehydes, 2-hydroxy-1,4-naphthoquinone, hydrazine derivatives, and ethyl acetoacetate catalyzed by MgCl2 in ethylene glycol. Simplicity, short reaction time, high yield, and an eco-friendly catalyst are the main advantages of this method. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：1104 / 1108

页数：5

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