Educational attainment does not influence brain aging

被引：66

作者：

Nyberg, Lars ^{[1
,2
,3
,4
]}

Magnussen, Fredrik ^{[4
]}

Lundquist, Anders ^{[3
]}

Baare, William ^{[5
]}

Bartres-Faz, David ^{[6
,7
]}

Bertram, Lars ^{[4
,8
]}

Boraxbekk, C. J. ^{[1
,3
,5
,9
]}

Brandmaier, Andreas M. ^{[10
,11
,12
]}

Drevon, Christian A. ^{[13
,14
]}

Ebmeier, Klaus ^{[15
]}

Ghisletta, Paolo ^{[16
]}

Henson, Richard N. ^{[17
]}

Junque, Carme ^{[6
,7
]}

Kievit, Rogier ^{[17
,18
]}

Kleemeyer, Maike ^{[10
]}

Knights, Ethan ^{[17
]}

Kuhn, Simone ^{[10
,19
]}

Lindenberger, Ulman ^{[10
,11
,12
]}

Penninx, Brenda W. J. H. ^{[20
]}

Pudas, Sara ^{[2
,3
]}

Sorensen, Oystein ^{[4
]}

Vaque-Alcazar, Lidia ^{[6
,7
]}

Walhovd, Kristine B. ^{[4
,21
]}

Fjell, Anders M. ^{[4
,21
]}

机构：

[1] Umea Univ, Dept Radiat Sci, Radiol, S-90187 Umea, Sweden

[2] Umea Univ, Dept Integrat Med Biol, S-90187 Umea, Sweden

[3] Umea Univ, Umea Ctr Funct Brain Imaging, S-90187 Umea, Sweden

[4] Univ Oslo, Ctr Lifespan Changes Brain & Cognit, N-0317 Oslo, Norway

[5] Copenhagen Univ Hosp, Danish Res Ctr Magnet Resonance, Ctr Funct & Diagnost Imaging & Res, DK-2650 Hvidovre, Denmark

[6] Univ Barcelona, Fac Med & Hlth Sci, Dept Med, Barcelona 08014, Spain

[7] Univ Barcelona, Neurosci Inst, Barcelona 08014, Spain

[8] Univ Lubeck, Lubeck Interdisciplinary Platform Genome Analyt, D-23538 Lubeck, Germany

[9] Copenhagen Univ Hosp, Inst Sports Med Copenhagen, DK-2400 Copenhagen, Denmark

[10] Max Planck Inst Human Dev, Ctr Lifespan Psychol, D-14195 Berlin, Germany

[11] Max Planck Univ Coll London Ctr Computat Psychiat, D-14195 Berlin, Germany

[12] Max Planck Univ Coll London Ctr Computat Psychiat, London WC1B 5EH, England

[13] Vitas AS, Res Pk, N-0349 Oslo, Norway

[14] Univ Oslo, Fac Med, Inst Basic Med Sci, Dept Nutr,Med, N-0317 Oslo, Norway

[15] Univ Oxford, Warneford Hosp, Oxford OX3 7JX, England

[16] Univ Geneva, Fac Psychol & Sci Educ, CH-1205 Geneva, Switzerland

[17] Univ Cambridge, Med Res Council Cognit & Brain Sci Unit, Dept Psychiat, Cambridge CB2 7EF, England

[18] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Cognit Neurosci Dept, Med Ctr, NL-6500 GL Nijmegen, Netherlands

[19] Univ Clin Hamburg Eppendorf, Dept Psychiat & Psychotherapy, D-20251 Hamburg, Germany

[20] Vrije Univ, Dept Psychiat, Amsterdam Univ, Med Ctr, NL-1081 HJ Amsterdam, Netherlands

[21] Oslo Univ Hosp, Dept Radiol & Nucl Med, N-0372 Oslo, Norway

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2021年 / 118卷 / 18期

基金：

英国生物技术与生命科学研究理事会; 欧洲研究理事会; 英国医学研究理事会; 欧盟地平线“2020”;

关键词：

education; aging; cerebral cortex; hippocampus; reserve;

D O I：

10.1073/pnas.2101644118

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Education has been related to various advantageous lifetime outcomes. Here, using longitudinal structural MRI data (4,422 observations), we tested the influential hypothesis that higher education translates into slower rates of brain aging. Cross-sectionally, education was modestly associated with regional cortical volume. However, despite marked mean atrophy in the cortex and hippocampus, education did not influence rates of change. The results were replicated across two independent samples. Our findings challenge the view that higher education slows brain aging.

引用

页数：3

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