Synthesis and Antimicrobial Activity of Some Novel [4-(1,2,3-thiadiazol-4-yl)phenoxy]methylene anchored 1,3,4-triazoles and 1,3,4-thiadiazoles

A series of novel [4-(1,2,3-thiadiazol-4-yl)phenoxy]methylene anchored 1,3,4-triazoles (8a, 8b, 8c, 8d, 8e, 8f, 8g, 8h) and 1,3,4-thiadiazoles (9a, 9b, 9c, 9d, 9e, 9f, 9g, 9h, 9i) were synthesized from thiosemicarbazide (7a, 7b, 7c, 7d, 7e, 7f, 7g, 7h, 7i, 7j). The structures of these newly synthesized compounds were confirmed on the basis of IR, H-1-NMR, mass spectral techniques, and elemental analysis. The in vitro antimicrobial screenings of the synthesized compounds were carried out against four bacterial pathogens, namely Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, Pseudomonas aeruginosa and three fungal pathogens Candida albicans, Aspergillus niger and Aspergillus clavatus, using broth microdilution minimum inhibitory concentration method. The compounds 7d, 7j, 8a, 9a, 9b, and 9i exhibited promising antibacterial activity against the tested strains, whereas some compounds were found to be active against one of the tested bacterial strains.