Preoperative Plasma Aldosterone Predicts Complete Remission of Type 2 Diabetes after Bariatric Surgery

被引：0

作者：

Ohira, Masahiro ^{[1
]}

Abe, Kazuki ^{[2
]}

Yamaguchi, Takashi ^{[2
]}

Onda, Hiroki ^{[2
]}

Yamaoka, Shuhei ^{[2
]}

Nakamura, Shoko ^{[2
]}

Tanaka, Shou ^{[2
]}

Watanabe, Yasuhiro ^{[2
]}

Nabekura, Taiki ^{[3
]}

Oshiro, Takashi ^{[3
]}

Nagayama, Daiji ^{[4
]}

Saiki, Atsuhito ^{[2
]}

Tatsuno, Ichiro ^{[2
,5
]}

机构：

[1] Toho Univ, Dept Internal Med, Div Diabet Metab & Endocrinol, Ohashi Med Ctr, Tokyo, Japan

[2] Toho Univ, Ctr Diabet Endocrine & Metab, Sakura Med Ctr, Chiba, Japan

[3] Toho Univ, Dept Surg, Sakura Med Ctr, Chiba, Japan

[4] Nagayama Clin, Dept Internal Med, Tochigi, Japan

[5] Chiba Prefectural Univ Hlth Sci, Chiba, Japan

来源：

OBESITY FACTS | 2022年 / 15卷 / 03期

关键词：

Bariatric surgery; Type; 2; diabetes; Plasma aldosterone concentration; Diabetes remission; INSULIN-RESISTANCE; GASTRIC BYPASS; DUODENOJEJUNAL BYPASS; SLEEVE GASTRECTOMY; GLYCEMIC CONTROL; WEIGHT-LOSS; SECRETION; SYSTEM;

D O I：

10.1159/000521855

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: Bariatric surgery (BS) has beneficial effects on body weight and type 2 diabetes. However, 44-52%, 20-40%, and 19-25% of patients with type 2 diabetes who undergo sleeve gastrectomy, sleeve gastrectomy with duodenal-jejunal bypass, and Roux-en-Y gastric bypass, respectively, show insufficient improvement 1 year after BS. It is thus important to predict the improvement in type 2 diabetes before BS. Many hormones are related to hyperglycemia. However, the relationship between hormones and improvement in type 2 diabetes after BS has not been studied. We aimed to evaluate the relationship between the improvement in type 2 diabetes and hormones in patients with obesity and type 2 diabetes who underwent BS. Methods: We retrospectively reviewed 79 patients with obesity and type 2 diabetes who underwent BS, with a follow-up period of 12 months. We analyzed the relationship between some clinical parameters and complete remission (CR) of type 2 diabetes after BS. Patients were divided into two groups (type 2 diabetes CR and non-CR). Multiple regression analysis was performed to determine the parameters associated with type 2 diabetes resolution after BS. Results: BS significantly improved body weight and glucose metabolism. Preoperative liver function, glycated hemoglobin (HbA1c), insulin secretion (homeostatic model assessment [HOMA]2-%B), renin activity, plasma aldosterone level, and duration of type 2 diabetes were significantly different between the CR and non-CR groups. Multiple regression analysis showed that preoperative HbA1c, HOMA2-%B, aldosterone concentration, and duration of type 2 diabetes were predictors of CR of type 2 diabetes after BS. Plasma aldosterone was the strongest predictor. Discussion/Conclusion: Preoperative plasma aldosterone levels were related to the CR of type 2 diabetes after BS. Measuring plasma aldosterone levels preoperatively is useful for predicting the CR of type 2 diabetes after BS.

引用

页码：373 / 383

页数：11

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