Microbiome-wide association studies link dynamic microbial consortia to disease

被引：509

作者：

Gilbert, Jack A. ^{[1
,4
]}

Quinn, Robert A. ^{[2
,3
]}

Debelius, Justine ^{[5
]}

Xu, Zhenjiang Z. ^{[5
]}

Morton, James ^{[6
]}

Garg, Neha ^{[2
,3
]}

Jansson, Janet K. ^{[7
]}

Dorrestein, Pieter C. ^{[2
,3
,4
,5
]}

Knight, Rob ^{[4
,5
,6
]}

机构：

[1] Univ Chicago, Dept Surg, 5841 S Maryland Ave, Chicago, IL 60637 USA

[2] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, Collaborat Mass Spectrometry Innovat Ctr, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Jacobs Sch Engn, Ctr Microbiome Innovat, La Jolla, CA 92093 USA

[5] Univ Calif San Diego, Dept Pediat, Sch Med, La Jolla, CA 92093 USA

[6] Univ Calif San Diego, Jacobs Sch Engn, Dept Comp Sci & Engn, La Jolla, CA 92093 USA

[7] Pacific NW Natl Lab, Earth & Biol Sci Directorate, Richland, WA 99354 USA

来源：

NATURE | 2016年 / 535卷 / 7610期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

HUMAN GUT MICROBIOME; N-OXIDE TMAO; FECAL MICROBIOTA; METABOLISM; REVEALS; OBESITY; SYSTEMS; CANCER; IDENTIFICATION; INFLAMMATION;

D O I：

10.1038/nature18850

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Rapid advances in DNA sequencing, metabolomics, proteomics and computational tools are dramatically increasing access to the microbiome and identification of its links with disease. In particular, time-series studies and multiple molecular perspectives are facilitating microbiome-wide association studies, which are analogous to genome-wide association studies. Early findings point to actionable outcomes of microbiome-wide association studies, although their clinical application has yet to be approved. An appreciation of the complexity of interactions among the microbiome and the host's diet, chemistry and health, as well as determining the frequency of observations that are needed to capture and integrate this dynamic interface, is paramount for developing precision diagnostics and therapies that are based on the microbiome.

引用

页码：94 / 103

页数：10

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