Phenanthrenoids from Juncus acutus L., new natural lipopolysaccharide-inducible nitric oxide synthase inhibitors

被引：31

作者：

Abdelhalim Behery, Fathi Abdelmohsen

Metwally Naeem, Zain Elabdin

Maatooq, Galal Taha

Abdelfattah Amer, Mohamed Mahmoud

Wen, Zhi-Hong

Sheu, Jyh-Horng

Ahmed, Atallah Fouad ^{[1
]}

机构：

[1] Mansoura Univ, Fac Pharm, Dept Pharmacognosy, Mansoura 35516, Egypt

[2] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2007年 / 55卷 / 08期

关键词：

Juncus acutus L; juncaceae; juncutol; phenanthrenoid; iNOS inhibitor; anti inflammatory activity;

D O I：

10.1248/cpb.55.1264

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The novel natural product juncutol (1), 1,4,7-trimethyl-8,9-dihydro-4H-cyclopentaldeflphenanthrene-2,6-diol, along with the three related metabolites juncusol (2), dehydrojuncusol (3), and 6-hydroxymethyl-1-methyl-5vinyl-9,10-dihydrophenanthrene-2-ol (4), were isolated from the rhizomes of Juncus acutus L. (Juncaceae) growing in Egypt. The structural identity of 1 was determined on the basis of spectroscopic analyses, including 2D NMR spectroscopy. The inhibitory effect of these natural products on the expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide-stimulated RAW264.7 macrophage cells was determined for the first time. The unprecedented symmetrical compound juncutol (1) was found to be the most potent inhibitor against the induction of the proinflammatory iNOS protein.

引用

页码：1264 / 1266

页数：3

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