Localisation of NADPH diaphorase activity and NOS immunoreactivity in astroglia in normal adult rat brain

被引：40

作者：

Gabbott, PLA

Bacon, SJ

机构：

[1] Univ. Department of Pharmacology, Oxford, OX1 3QT, Mansfield Road

来源：

BRAIN RESEARCH | 1996年 / 714卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

constitutive NOS; nitric oxide; GFAP; weak aldehyde fixation;

D O I：

10.1016/0006-8993(95)01509-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study demonstrates the co-localisation of NADPH diaphorase activity and GFAP immunoreactivity in non-neuronal cells in weakly fixed brain sections from normal adult rats. The presence of GFAP immunoreactivity in these cells indicates that they are astroglia. In addition, cells possessing the morphological characteristics of astroglia were weakly immunoreactive for the endothelial isoform of nitric oxide synthase (eNOS) - these cells also co-localised NADPH diaphorase activity. Furthermore, cells immunoreactive for eNOS displayed GFAP immunoreactive processes. This cytochemical evidence strongly suggests that resting astroglia are potential sources of nitric oxide - a powerful modulator of cell activity.

引用

页码：135 / 144

页数：10

共 27 条

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[Anonymous], 1993, BIOL DATA ANAL PRACT

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