Early exposure to allergen: Is this the cat's meow, or are we barking up the wrong tree?

被引:31
作者
Apter, AJ [1 ]
机构
[1] Univ Penn, Dept Med, Div Pulm Allergy & Crit Care Med, Philadelphia, PA 19104 USA
关键词
allergy; asthma; adult; children; sensitization; cat; dog; epidemiology; selection bias; effect modification;
D O I
10.1067/mai.2003.1417
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Several recent studies have suggested that exposure to cat and dog allergen in infancy is protective against the subsequent risk of allergic sensitization and asthma. The methodologic problems to be overcome in clinical research addressing these hypotheses are complex. Appreciation of these studies requires an assessment of the design and adequacy of variables measuring exposures, outcomes, and confounders. It includes understanding the role of effect modification. This article discusses some of the epidemiologic issues in interpreting these studies. Review of relevant epidemiology demonstrates that much research remains to be performed before these interesting hypothesis are proved or disproved.
引用
收藏
页码:938 / 946
页数:9
相关论文
共 34 条
[1]   Early, current and past pet ownership: associations with sensitization, bronchial responsiveness and allergic symptoms in school children [J].
Anyo, G ;
Brunekreef, B ;
de Meer, G ;
Aarts, F ;
Janssen, NAH ;
van Vliet, P .
CLINICAL AND EXPERIMENTAL ALLERGY, 2002, 32 (03) :361-366
[2]  
Bener A, 1995, Allerg Immunol (Paris), V27, P190
[3]   Concentration of cat (Fel d 1), dog (Can f 1) and mite (Der f 1 and Der p 1) allergens in the clothing and school environment of Swedish schoolchildren with and without pets at home [J].
Berge, M ;
Munir, AK ;
Dreborg, S .
PEDIATRIC ALLERGY AND IMMUNOLOGY, 1998, 9 (01) :25-30
[4]   PETS, ALLERGY AND RESPIRATORY SYMPTOMS IN CHILDREN [J].
BRUNEKREEF, B ;
GROOT, B ;
HOEK, G .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 1992, 21 (02) :338-342
[5]   Asthma guidelines: A changing paradigm to improve asthma care [J].
Busse, WW ;
Lenfant, C ;
Lemanske, RF .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2002, 110 (05) :703-705
[6]   Day care attendance in the first year of life and illnesses of the upper and lower respiratory tract in children with a familial history of atopy [J].
Celedon, JC ;
Litonjua, AA ;
Weiss, ST ;
Gold, DR .
PEDIATRICS, 1999, 104 (03) :495-500
[7]   Exposure to cat allergen, maternal history of asthma, and wheezing in first 5 years of life [J].
Celedón, JC ;
Litonjua, AA ;
Ryan, L ;
Platts-Mills, T ;
Weiss, ST ;
Gold, DR .
LANCET, 2002, 360 (9335) :781-782
[8]   Asthma, rhinitis, and skin test reactivity to aeroallergens in families of asthmatic subjects in Anqing, China [J].
Celedón, JC ;
Palmer, LJ ;
Weiss, ST ;
Wang, BY ;
Fang, Z ;
Xu, XP .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2001, 163 (05) :1108-1112
[9]   Limitations of a home characteristics questionnaire as a predictor of indoor allergen levels [J].
Chew, GL ;
Burge, HA ;
Dockery, DW ;
Muilenberg, ML ;
Weiss, ST ;
Gold, DR .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1998, 157 (05) :1536-1541
[10]  
Custovic A, 2001, J ALLERGY CLIN IMMUN, V108, P537, DOI 10.1067/mai.2001.118599