Photodynamic activity of water-soluble phthalocyanine zinc(II) complexes against pathogenic microorganisms

被引：114

作者：

Mantareva, Vanya

Kussovski, Veselin

Angelov, Ivan

Borisova, Ekaterina

Avramov, Latchezar

Schnurpfeil, Guenter

Woehrle, Dieter

机构：

[1] Bulgarian Acad Sci, Inst Organ Chem, BU-1113 Sofia, Bulgaria

[2] Bulgarian Acad Sci, Stephan Angeloff Inst Microbiol, BU-1113 Sofia, Bulgaria

[3] Bulgarian Acad Sci 72, Inst Elect, Sofia 1784, Bulgaria

[4] Univ Bremen, Inst Organ & Macromol Chem, D-28334 Bremen, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2007年 / 15卷 / 14期

关键词：

photodynamic inactivation; phthalocyanines; light fluence; bacteria and fungi;

D O I：

10.1016/j.bmc.2007.04.069

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Photodynamic activity of tetrakis-(3-methylpyridyloxy)- and tetrakis-(4-sulfophenoxy)-phthalocyanine zinc(II) toward the gram-positive Staphylococcus aureus, the gram-negative Pseudomonas aeruginosa, and the fungi Candida albicans was studied. The drug uptake dependency with an inverse behavior to the cell density was observed. The cationic photosensitizer completely inactivated S. aureus and C. albicans, and with 4log(10) P. aeruginosa. The photoinactivation at mild experimental conditions, such as drug dose of 1.5 mu M and fluence of 50 mW cm(-2) for 10 min irradiation time, was shown. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：4829 / 4835

页数：7

共 33 条

[1] Inactivation of photosensitizing merocyanine dyes by plasma, serum and serum components [J].