Facile Synthesis of Novel Pyrimido[1,2-a]pyrimidin-4-ones from Highly Reactive Malonates

被引：10

作者：

Gullu, Mustafa ^{[1
]}

Dincsonmez, Ali ^{[1
]}

Ozyavas, Oznur ^{[1
]}

机构：

[1] Ankara Univ, Fac Sci, Dept Chem, TR-06100 Ankara, Turkey

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 2010卷 / 11期

关键词：

Nitrogen heterocycles; Fused-ring systems; Cyclization; Condensation; Malonates; REGIOSELECTIVE SYNTHESIS; HETEROCYCLES; DERIVATIVES; PYRIMIDINE; INHIBITORS; GUANIDINE; ACRYLONITRILE; HYDROXY; ANALOGS;

D O I：

10.1002/ejoc.200901419

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A very simple and efficient procedure for the synthesis of novel 2-hydroxy-4H-pyrimido[1,2-a]pyrimidin-4-ones is described. Title compounds were obtained from the room temperature reaction of 2-aminopyrimidine and its substituted derivatives with bis(2,4,6-trichlorophenyl) malonates. High product yields were observed under optimized conditions. Applicability and reactivity of a range of substituted and unsubstituted phenyl malonates were also investigated. Structural identification of all new compounds was accomplished by spectroscopic methods and elemental analysis.

引用

页码：2113 / 2120

页数：8

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