Effect of Lornoxicam Therapy on Expression of TLR2 and TLR4 mRNA during Systemic Complications of Acute Pancreatitis

被引：8

作者：

Gorskii, V. A. ^{[1
]}

Agapov, M. A. ^{[1
]}

Khoreva, M. V. ^{[1
]}

Petrov, V. A. ^{[1
]}

Kravchenko, A. Yu. ^{[1
]}

Battaev, A. I. ^{[2
]}

机构：

[1] NI Pirogov Russian Natl Res Med Univ, Moscow, Russia

[2] Fed Secur Serv Russian Federat, Head Mil Clin Hosp, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2014年 / 158卷 / 01期

关键词：

severe acute pancreatitis; lornoxicam; Toll-like receptor 2; Toll-like receptor 4; LIGANDS;

D O I：

10.1007/s10517-014-2680-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Primary pancreatic injury that occurs in acute pancreatitis leads to necrosis of pancreatic cells and is accompanied by the development systemic inflammatory response of varying severity. Systemic inflammatory response, in turn, can lead to the development of multiple organ dysfunction syndrome and death of patients. The release of damage-associated molecular patterns into the extracellular space is the trigger pathological mechanism underlying these processes. The released patterns exert their effects via Toll-like receptors (TLR). These findings suggest that TLR can be considered a new target for therapeutic intervention in acute pancreatitis. We studied mRNA expression of TLR2 and TLR4 in the peripheral blood mononuclear cells from the patients with acute pancreatitis and showed a decrease in the examined parameters associated with lornoxicam treatment. Anti-mediator therapy decreased mortality in these patients.

引用

页码：13 / 15

页数：3