First experience of the AML-Berlin-Frankfurt-Munster group in pediatric patients with standard-risk acute promyelocytic leukemia treated with arsenic trioxide and all-trans retinoid acid

被引：37

作者：

Creutzig, Ursula ^{[1
]}

Dworzak, Michael N. ^{[2
,3
]}

Bochennek, Konrad ^{[4
]}

Faber, Joerg ^{[5
]}

Flotho, Christian ^{[6
]}

Graf, Norbert ^{[7
]}

Kontny, Udo ^{[8
]}

Rossig, Claudia ^{[9
]}

Schmid, Irene ^{[10
]}

von Stackelberg, Arend ^{[11
]}

Mueller, Jans-Enno ^{[12
]}

von Neuhoff, Christine ^{[12
]}

Reinhardt, Dirk ^{[12
]}

von Neuhoff, Nils ^{[12
]}

机构：

[1] Childrens Hosp, Hannover Med Sch, Dept Pediat Hematol Oncol, Hannover, Germany

[2] St Anna Childrens Hosp, Dept Pediat, Vienna, Austria

[3] Med Univ Vienna, Childrens Canc Res Inst, Vienna, Austria

[4] Goethe Univ Frankfurt, Div Pediat Hematol & Oncol, Frankfurt, Germany

[5] Johannes Gutenberg Univ Mainz, Univ Med, Dept Pediat Hematol Oncol, Mainz, Germany

[6] Univ Med Ctr, Div Pediat Hematol Oncol, Freiburg, Germany

[7] Saarland Univ, Dept Pediat Oncol Hematol, Homburg, Germany

[8] Rhein Westfal TH Aachen, Fac Med, Div Pediat Hematol Oncol & Stem Cell Transplant, Aachen, Germany

[9] Univ Childrens Hosp Muenster, Dept Pediat Hematol & Oncol, Munster, Germany

[10] Ludwig Maximilians Univ Munchen, Dr von Hauner Childrens Hosp, Dept Pediat Hematol & Oncol, Munich, Germany

[11] Charite Univ Med Ctr Berlin, Dept Pediat Oncol Hematol, Berlin, Germany

[12] Univ Duisburg Essen, Dept Pediat Hematol Oncol, Essen, Germany

来源：

PEDIATRIC BLOOD & CANCER | 2017年 / 64卷 / 08期

关键词：

acute promyelocytic leukemia; ATO; ATRA; children; FOLLOW-UP; CHILDREN; TRIAL;

D O I：

10.1002/pbc.26461

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recently, studies in adults with acute promyelocytic leukemia (APL) showed high cure rates in low-risk patients treated with all-trans retinoid acid (ATRA) and arsenic trioxide (ATO), while toxicities were significantly reduced compared to the standard treatment with ATRA and chemotherapy. Here we report about first experience with 11 pediatric patients with low-risk APL treated with ATRA and ATO. All patients stayed in molecular remission. All suffered from hyperleukocytosis. Two patients experienced reversible severe side effects. One suffered from osteonecroses at both femurs, seizures, as well as posterior reversible encephalopathy syndrome, the other patient had an abducens paresis.

引用

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