Spontaneous dynamics of synaptic weights in stochastic models with pair-based spike-timing-dependent plasticity

We investigate spike-timing dependent plasticity (STPD) in the case of a synapse connecting two neuronal cells. We develop a theoretical analysis of several STDP rules using Markovian theory. In this context there are two different timescales, fast neuronal activity and slower synaptic weight updates. Exploiting this timescale separation, we derive the long-time limits of a single synaptic weight subject to STDP. We show that the pairing model of presynaptic and postsynaptic spikes controls the synaptic weight dynamics for small external input on an excitatory synapse. This result implies in particular that mean-field analysis of plasticity may miss some important properties of STDP. Anti-Hebbian STDP favors the emergence of a stable synaptic weight. In the case of an inhibitory synapse the pairing schemes matter less, and we observe convergence of the synaptic weight to a nonnull value only for Hebbian STDP. We extensively study different asymptotic regimes for STDP rules, raising interesting questions for future work on adaptative neuronal networks and, more generally, on adaptative systems.