Interleukin 12 in part regulates gamma interferon release in human whole blood stimulated with Leptospira interrogans

被引：35

作者：

de Fost, M

Hartskeerl, RA

Groenendijk, MR

van der Poll, T

机构：

[1] Univ Amsterdam, Acad Med Ctr, Lab Expt Internal Med, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Dept Infect Dis Trop Med & AIDS, NL-1105 AZ Amsterdam, Netherlands

[3] WHO, FAO, Royal Trop Inst, Collaborating Ctr Reference & Res Leptospirosis, NL-1105 AZ Amsterdam, Netherlands

来源：

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 2003年 / 10卷 / 02期

关键词：

D O I：

10.1128/CDLI.10.2.332-335.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Heat-killed pathogenic Leptospira interrogans serovar rachmati induced the production of gamma interferon (IFN-gamma) and the IFN-gamma-inducing cytokines interleukin-12p40 (IL-12p40) and tumor necrosis factor alpha in human whole blood in vitro. The production of IFN-gamma was largely dependent on IL-12. These data establish that pathogenic leptospires can stimulate the production of type I cytokines involved in cellular immunity.

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页码：332 / 335

页数：4

相关论文

共 18 条

[1] Cellular responses to interferon-gamma [J].

Boehm, U ;

Klamp, T ;

Groot, M ;

Howard, JC .

ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :749-795

[2] Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro [J].

Carson, WE ;

Ross, ME ;

Baiocchi, RA ;

Marien, MJ ;

Boiani, N ;

Grabstein, K ;

Caligiuri, MA .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (06) :2578-2582

[3] The interleukin-12/interleukin-12-receptor system: Role in normal and pathologic immune responses [J].

Gately, MK ;

Renzetti, LM ;

Magram, J ;

Stern, AS ;

Adorini, L ;

Gubler, U ;

Presky, DH .

ANNUAL REVIEW OF IMMUNOLOGY, 1998, 16 :495-521

[4]

Heinzel FP, 1997, J IMMUNOL, V158, P4381

[5] DIFFERENTIATION OF PATHOGENIC AND SAPROPHYTIC LEPTOSPIRES .I. GROWTH AT LOW TEMPERATURES [J].

JOHNSON, RC ;

HARRIS, VG .

JOURNAL OF BACTERIOLOGY, 1967, 94 (01) :27-&

[6] Proinflammatory effects of IL-10 during human endotoxemia [J].

Lauw, FN ;

Pajkrt, D ;

Hack, CE ;

Kurimoto, M ;

van Deventer, SJH ;

van der Poll, T .

JOURNAL OF IMMUNOLOGY, 2000, 165 (05) :2783-2789

[7] Elevated plasma concentrations of interferon (IFN)-γ and the IFN-γ-inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis [J].

Lauw, FN ;

Simpson, AJH ;

Prins, JM ;

Smith, MD ;

Kurimoto, M ;

van Deventer, SJH ;

Speelman, P ;

Chaowagul, W ;

White, NJ ;

van der Poll, T .

JOURNAL OF INFECTIOUS DISEASES, 1999, 180 (06) :1878-1885

[8] Reduced Th1, but not Th2, cytokine production by lymphocytes after in vivo exposure of healthy subjects to endotoxin [J].

Lauw, FN ;

ten Hove, T ;

Dekkers, PEP ;

de Jonge, E ;

van Deventer, SJH ;

van der Poll, T .

INFECTION AND IMMUNITY, 2000, 68 (03) :1014-1018

[9] Leptospirosis [J].

Levett, PN .

CLINICAL MICROBIOLOGY REVIEWS, 2001, 14 (02) :296-+

[10] Protective killed Leptospira borgpetersenii vaccine induces potent Th1 immunity comprising responses by CD4 and γδ T lymphocytes [J].

Naiman, BM ;

Alt, D ;

Bolin, CA ;

Zuerner, R ;

Baldwin, CL .

INFECTION AND IMMUNITY, 2001, 69 (12) :7550-7558